Multicenter comparison of once- and twice-daily isradipine to hydrochlorothiazide for the treatment of hypertension in elderly patients
| Autor: | Bruce P. Hamilton, Ralph E. Cutler, Gilbert Neri, Gerald H. Stein, Katherine P. Matthews, Walter M. Kirkendall, Alan P. Abrams, Jordan L. Holtzman |
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| Rok vydání: | 1990 |
| Předmět: |
Male
Pyridines medicine.medical_treatment Total response Blood Pressure Placebo Drug Administration Schedule Hydrochlorothiazide Double-Blind Method medicine Humans Pharmacology (medical) Antihypertensive Agents Aged Pharmacology Aged 80 and over Chemotherapy Isradipine business.industry Sodium Middle Aged Blood pressure Anesthesia Hypertension Female Diuretic business Dihydropyridine Calcium Channel Blocker medicine.drug |
| Zdroj: | Clinical pharmacology and therapeutics. 48(5) |
| ISSN: | 0009-9236 |
| Popis: | After 8 weeks of isradipine, a twice-a-day dihydropyridine calcium channel blocker, 49% of elderly patients showed a complete response (sitting diastolic blood pressure less than or equal to 85 mm Hg) and 36% showed a partial response (sitting diastolic blood pressure decrease greater than or equal to 10 mm Hg) for an 85% total response rate. Hydrochlorothiazide gave a complete response in 36% of the patients and a partial response in 33%, for a 69% total response rate (p less than 0.0046). Because elderly subjects have reduced clearance for many drugs, we determined how those who responded to twice-a-day administration would respond to once-a-day administration. After 4 weeks of isradipine administered once a day, 54% of the patients showed a complete or partial response, whereas 38% of the patients who were changed to placebo showed a response. In contrast, 82% of patients receiving hydrochlorothiazide once a day showed a response, whereas 60% of patients who were changed to placebo showed a response. These data indicate that the standard formulation of isradipine was not effective when administered once a day. |
| Databáze: | OpenAIRE |
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