Synthesis and characterization of pH sensitive hydrogel nanoparticles based on poly(N-isopropyl acrylamide-co-methacrylic acid)
| Autor: | C E Belman-Flores, A. May-Pat, Humberto Vázquez-Torres, Wilberth Herrera-Kao, Nayeli Rodríguez-Fuentes, A.I. Oliva, José M. Cervantes-Uc, R.F. Vargas-Coronado, Juan V. Cauich-Rodríguez |
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| Rok vydání: | 2020 |
| Předmět: |
Materials science
0206 medical engineering Biomedical Engineering Biophysics Nanoparticle Bioengineering 02 engineering and technology Hemolysis Biomaterials chemistry.chemical_compound Polymethacrylic Acids Materials Testing Toxicity Tests Copolymer Animals Humans Particle Size Fourier transform infrared spectroscopy Cells Cultured Acrylamides Blood Cells Hydrogels Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology 020601 biomedical engineering Freeze Drying Methacrylic acid chemistry Acrylamide Drug delivery Self-healing hydrogels Methacrylates Nanoparticles Cattle Particle size 0210 nano-technology Nuclear chemistry |
| Zdroj: | Journal of Materials Science: Materials in Medicine. 31 |
| ISSN: | 1573-4838 0957-4530 |
| Popis: | In this work, pH-sensitive hydrogel nanoparticles based on N-isopropyl acrylamide (NIPAM) and methacrylic acid (MAA) at various molar ratios, were synthesized and characterized in terms of physicochemical and biological properties. FTIR and 1HNMR spectra confirmed the successful synthesis of the copolymer that formed nanoparticles. AFM images and FE-SEM micrographs showed that nanoparticles were spherical, but their round-shape was slightly compromised with MAA content; besides, the size of particles tends to decrease as MAA content increased. The hydrogels nanoparticles also exhibited an interesting pH-sensitivity, displaying changes in its particle size when changes in pH media occurred. Biological characterization results indicate that all the synthesized particles are non-cytotoxic to endothelial cells and hemocompatible, although an increase of MAA content leads to a slight increase in the hemolysis percentage. Therefore, the pH-sensitivity hydrogels may serve as a versatile platform as self-regulated drug delivery systems in response to environmental pH changes. |
| Databáze: | OpenAIRE |
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