Clinical Evaluation of an Acellular Allograft Dermal Matrix in Full-Thickness Burns
| Autor: | David J. Wainwright, Richard J. Kagan, William W. Monafo, David N. Herndon, Michael R. Madden, Alan R. Dimick, Arnold Luterman, John F. Hunt, David M. Heimbach, Kevin Sittig |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Neovascularization Physiologic Pilot Projects Lymphocyte Activation Transplantation Autologous Basement Membrane Neovascularization Injury Severity Score Humans Medicine Fibroblast General Nursing Aged Skin Aged 80 and over Analysis of Variance Wound Healing integumentary system business.industry Graft Survival Rehabilitation Histology Skin Transplantation Fibroblasts Middle Aged Prognosis Extracellular Matrix Surgery Transplantation Plastic surgery surgical procedures operative medicine.anatomical_structure General Health Professions Emergency Medicine Feasibility Studies Female Full thickness sense organs medicine.symptom Burns business Dermal matrix Clinical evaluation |
| Zdroj: | Journal of Burn Care & Rehabilitation. 17:124-136 |
| ISSN: | 0273-8481 |
| Popis: | A multicenter clinical study assessed the ability of an acellular allograft dermal matrix to function as a permanent dermal transplant in full-thickness and deep partial-thickness burns. The study consisted of a pilot phase (24 patients) to identify the optimum protocol and a study phase (43 patients) to evaluate graft performance. Each patient had both a test and a mirror-image or contiguous control site. At the test site, the dermal matrix was grafted to the excised wound base and a split-thickness autograft was simultaneously applied over it. The control site was grafted with a split-thickness autograft alone. Fourteen-day take rates of the dermal matrix were statistically equivalent to the control autografts. Histology of the dermal matrix showed fibroblast infiltration, neovascularization, and neoepithelialization without evidence of rejection. Wound assessment over time showed that thin split-thickness autografts plus allograft dermal matrix were equivalent to thicker split-thickness autografts. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|