Polyethylene glycol-induced motor recovery after total spinal transection in rats

Autor:	Ming Li, Shuai Ren, Qiong Wu, Jun Wu, Ya Shan Guo, Yan Xue, Qing Miao, Ze Han Liu, Sheng Yu Wang, Zhen Xue, Kuang Fu, Xiao Ping Ren, Xin Zhao, Sergio Canavero, Yun Long Zhao, Li Ting Hou
Rok vydání:	2017
Předmět:	Male medicine.medical_specialty Cord medicine.medical_treatment Motor Activity Polyethylene Glycols Random Allocation 03 medical and health sciences 0302 clinical medicine Evoked Potentials Somatosensory Physiology (medical) Paralysis Animals Medicine Pharmacology (medical) Saline Spinal cord injury Spinal Cord Injuries Pharmacology business.industry Original Articles Recovery of Function Spinal cord medicine.disease Magnetic Resonance Imaging Rats Surgery Disease Models Animal Psychiatry and Mental health Diffusion Tensor Imaging Neuroprotective Agents medicine.anatomical_structure Spinal Cord Somatosensory evoked potential 030220 oncology & carcinogenesis Anesthesia Vertebrectomy Animal studies medicine.symptom business 030217 neurology & neurosurgery
Zdroj:	CNS Neuroscience & Therapeutics. 23:680-685
ISSN:	1755-5930
DOI:	10.1111/cns.12713
Popis:	SummaryAims Despite more than a century of research, spinal paralysis remains untreatable via biological means. A new understanding of spinal cord physiology and the introduction of membrane fusogens have provided new hope that a biological cure may soon become available. However, proof is needed from adequately powered animal studies. Methods and results Two groups of rats (n=9, study group, n=6 controls) were submitted to complete transection of the dorsal cord at T10. The animals were randomized to receive either saline or polyethylene glycol (PEG) in situ. After 4 weeks, the treated group had recovered ambulation vs none in the control group (BBB scores; P=.0145). One control died. All animals were studied with somatosensory-evoked potentials (SSEP) and diffusion tensor imaging (DTI). SSEP recovered postoperatively only in PEG-treated rats. At study end, DTI showed disappearance of the transection gap in the treated animals vs an enduring gap in controls (fractional anisotropy/FA at level: P=.0008). Conclusions We show for the first time in an adequately powered study that the paralysis attendant to a complete transection of the spinal cord can be reversed. This opens the path to a severance-reapposition cure of spinal paralysis, in which the injured segment is excised and the two stumps approximated after vertebrectomy/diskectomies.
Databáze:	OpenAIRE
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