Effect of 3,4-dihydroxyphenylacetic acid on catecholamines and serotonin in rat striatum
| Autor: | J. Donaldson, André Barbeau, K. Yamada, Minnich Jl |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Male
medicine.medical_specialty Serotonin 3 4-Dihydroxyphenylacetic acid Metabolite Dopamine Striatum Catechol O-Methyltransferase Tritium Basal Ganglia Rat striatum Norepinephrine (medication) chemistry.chemical_compound Norepinephrine Catecholamines Internal medicine medicine Animals Homogentisic Acid Monoamine Oxidase Phenylacetates Behavior Animal Decreased Concentration Corpus Striatum Rats Endocrinology nervous system Neurology chemistry Neurology (clinical) medicine.drug |
| Zdroj: | Journal of the neurological sciences. 18(3) |
| ISSN: | 0022-510X |
| Popis: | The effects of 3,4-dihydroxyphenylacetic acid (DOPAC) injection into the left lateral ventricle of rats on the concentration of biogenic amines in the striatum were observed. The behaviour of rats was recorded for 10 min after injection of DOPAC and the animals were then sacrificed. With low doses of DOPAC (0.06–1.49 mM ) decreased dopamine and norepinephrine concentrations were found. With high doses of DOPAC (2.37–11.83 mM ) increased concentration of catecholamines and decreased concentration of serotonin were seen. At low doses of DOPAC there was some slight sedation, and at high doses definite hypersensitivity was noted. The present experiments indicate that DOPAC is probably more than an inactive metabolite and may have a role to play in the feed-back control of catecholamine metabolism, especially when abnormal concentrations are produced through drug treatment. |
| Databáze: | OpenAIRE |
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