Bronchiolo-alveolar Carcinoma—Cell of Origin
| Autor: | S. D. Greenberg, H. J. Spjut, M. N. Smith |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Male
Cytoplasm Cell type Pathology medicine.medical_specialty Lung Neoplasms Bronchiole Cell of origin Cell Biology Cytoplasmic Granules Endoplasmic Reticulum medicine Carcinoma Humans Aged Cell Nucleus Inclusion Bodies Cell Membrane Mucins Desmosomes General Medicine Adenocarcinoma Bronchiolo-Alveolar Middle Aged respiratory system medicine.disease Mitochondria Intercellular Junctions medicine.anatomical_structure Vacuoles Ultrastructure Adenocarcinoma Female Stem cell |
| Zdroj: | American Journal of Clinical Pathology. 63:153-167 |
| ISSN: | 1943-7722 0002-9173 |
| DOI: | 10.1093/ajcp/63.2.153 |
| Popis: | Bronchiolo-alveolar carcinoma is the least common of the primary pulmonary carcinomas, and there is controversy as to its cell of origin. In this light- and electron microscopic study of five bronchiolo-alveolar carcinomas, at least two cell types were found, both of bronchiolar origin. One cell type is a metaplastic bronchiolar mucous cell and the other a bronchiolar stem cell that has ultrastructural features of both the respiratory ciliated and the respiratory nonciliated ("Clara") cell. It would not be unusual if tumors of the bronchiolo-alveolar region differentiate into cells of either the bronchiole or the alveolus, for embryologically they have a common origin. However, as information about the ultrastructure of these tumors accumulates, it is becoming apparent that an alveolar-cell carcinoma must be a rare occurrence. Hyperplastic Type II aleveolar epithelial cells may be found about the margins of these tumors and can be mistaken for the neoplastic cells. |
| Databáze: | OpenAIRE |
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