4-Locus high-resolution HLA allele and haplotype frequencies in Costa Ricans from Guanacaste
| Autor: | Jeremy E. Stein, Bronwen E. Shaw, Steven G.E. Marsh, Gilbert Arrieta-Molina, Lizbeth Salazar-Sánchez, J. Alejandro Madrigal, Juan José Madrigal-Sánchez, Esteban Arrieta-Bolaños |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Genetics education.field_of_study Immunology Haplotype Population Medizin High resolution Locus (genetics) General Medicine Human leukocyte antigen Biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Genotype Immunology and Allergy Allele education Allele frequency geographic locations 030215 immunology |
| Zdroj: | Human immunology. 80(7) |
| ISSN: | 1879-1166 |
| Popis: | A total of 110 Costa Rican Mestizos from the province of Guanacaste were genotyped at high-resolution for the human leukocyte antigen loci HLA-A, -B, -C, and -DRB1 using sequence-based typing methods. The respective allele and extended haplotype frequencies, as well as Hardy-Weinberg proportions were calculated. The most frequent extended haplotype identified was A*24:02:01-B*35:12:01-C*04:01:01-DRB1*04:07:01G, with an estimated frequency of 2.73%. No deviation from Hardy-Weinberg Equilibrium was detected at any of the loci studied. The HLA genotypic data of the population sample reported here are available publicly in the Allele Frequencies Net Database under the population name "Costa Rica Guanacaste Mestizo" and the identifier AFN3609. |
| Databáze: | OpenAIRE |
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