Expression of microRNA-222 in serum of patients with Alzheimer's disease
| Autor: | Linqing Zou, Li Qian, Hongxia Nie, Chuanqi Wang, Jiandong Jiang, Aixia Zhuang, Qinghong Zeng, Haojiang Zhang, Fang Zhou, Shanhua Yu |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Cancer Research medicine.medical_specialty Comorbidity Biology Biochemistry Gastroenterology 03 medical and health sciences Alzheimer Disease Risk Factors Internal medicine microRNA Genetics medicine Cluster Analysis Humans Circulating MicroRNA Molecular Biology Aged Oncogene Microarray analysis techniques Gene Expression Profiling Computational Biology Middle Aged medicine.disease Molecular medicine Gene expression profiling MicroRNAs 030104 developmental biology Oncology Immunology Molecular Medicine Biomarker (medicine) Female Alzheimer's disease Biomarkers |
| Zdroj: | Molecular Medicine Reports. 16:5575-5579 |
| ISSN: | 1791-3004 1791-2997 |
| Popis: | The aim of the present study was to determine the association between Alzheimer's disease (AD) and microRNA‑222 in the serum of patients with AD. The expression of microRNAs was detected and the results were verified using microarray analysis and reverse transcription‑quantitative polymerase chain reaction. The results indicated that there were 35 strips of microRNA in the mild AD group, in which the difference of expression signal was >500 IU/ml. There were 26 strips of microRNA with a difference in expression signal of >500 IU/ml in the mild and moderate AD groups. The downregulation of microRNA‑222 in the mild and moderate groups was statistically significant (P |
| Databáze: | OpenAIRE |
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