Tumor Type-Dependent Function of the Par3 Polarity Protein in Skin Tumorigenesis
| Autor: | Wilhelmina E. van Riel, Tomonori Hirose, Sandra Iden, Ronny Schäfer, Shigeo Ohno, Ji-Ying Song, John G. Collard |
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| Rok vydání: | 2012 |
| Předmět: |
Keratinocytes
Cancer Research Skin Neoplasms Transgene Cell Cycle Proteins Mice Transgenic Biology medicine.disease_cause Mice Cell polarity medicine Animals Tissue homeostasis Cells Cultured Protein Kinase C Adaptor Proteins Signal Transducing Cell Proliferation Skin Cell growth Signal transducing adaptor protein Cell Polarity Cell Biology medicine.disease Cell biology Keratoacanthoma Cell Transformation Neoplastic Oncology Apoptosis Immunology Skin cancer Carcinogenesis Cell Adhesion Molecules |
| Zdroj: | Cancer Cell. 22(3):389-403 |
| ISSN: | 1535-6108 |
| DOI: | 10.1016/j.ccr.2012.08.004 |
| Popis: | SummaryCell polarization is crucial during development and tissue homeostasis and is regulated by conserved proteins of the Scribble, Crumbs, and Par complexes. In mouse skin tumorigenesis, Par3 deficiency results in reduced papilloma formation and growth. Par3 mediates its tumor-promoting activity through regulation of growth and survival, since Par3 deletion increases apoptosis and reduces growth in vivo and in vitro. In contrast, Par3-deficient mice are predisposed to formation of keratoacanthomas, cutaneous tumors thought to originate from different cellular origin and frequently observed in humans. Par3 expression is reduced in both mouse and human keratoacanthomas, indicating tumor-suppressive properties of Par3. Our results identify a dual function of Par3 in skin cancer, with both pro-oncogenic and tumor-suppressive activity depending on the tumor type. |
| Databáze: | OpenAIRE |
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