Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection

Autor:	James J. Hobson, Paul Curley, A. B. Dwyer, Usman Arshad, Helen Box, Andrew Owen, Henry Pertinez, Christopher David, Tom O. McDonald, Neill J. Liptrott, Jonathan Massam, Alison C. Savage, Joanne Sharp, Steve P. Rannard, Rajith K. R. Rajoli, Megan Neary, Anthony Valentijn, Catherine Unsworth, Lee Tatham
Rok vydání:	2021
Předmět:	Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 02 engineering and technology Pharmacology Antiviral Agents Injections Intramuscular 03 medical and health sciences Immune system In vivo medicine Humans General Materials Science Niclosamide 030304 developmental biology 0303 health sciences Chemistry SARS-CoV-2 021001 nanoscience & nanotechnology COVID-19 Drug Treatment Long acting Nanoparticles 0210 nano-technology Intramuscular injection Insoluble drug medicine.drug
Zdroj:	Nanoscale. 13(13)
ISSN:	2040-3372
Popis:	The control of COVID-19 across the world requires the formation of a range of interventions including vaccines to elicit an immune response and immunomodulatory or antiviral therapeutics. Here, we demonstrate the nanoparticle formulation of a highly insoluble drug compound, niclosamide, with known anti SARS-CoV-2 activity as a cheap and scalable long-acting injectable antiviral candidate.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c545d76f781bdecb39e3ee00816ac39e https://pubmed.ncbi.nlm.nih.gov/33885522 Zobrazit plný text záznamu