Impact of porcine maternal aerobic exercise training during pregnancy on endothelial cell function of offspring at birth
| Autor: | Christopher A. Bidwell, Kallie B. Foust, Martin Bahls, Ryan D. Sheldon, Sean C. Newcomer, Ryan A. Cabot, Pardis Taheripour |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Pregnancy Electrical impedance myography business.industry Offspring Medicine (miscellaneous) Bradykinin Vasodilation medicine.disease chemistry.chemical_compound Endocrinology chemistry Internal medicine medicine.artery medicine Aerobic exercise Thoracic aorta Sodium nitroprusside business medicine.drug |
| Zdroj: | Journal of developmental origins of health and disease. 3(1) |
| ISSN: | 2040-1744 |
| Popis: | The purpose of this investigation was to test the hypothesis that maternal exercise training during pregnancy enhances endothelial function in offspring at birth. Six-month-old gilts (n = 8) were artificially inseminated and randomized into exercise-trained (n = 4) and sedentary groups (n = 4). Exercise training consisted of 15 weeks of treadmill exercise. The thoracic aorta of offspring were harvested within 48 h after birth and vascular responsiveness to cumulative doses of endothelium-dependent (bradykinin: 10-11-10-6 M) and independent (sodium nitroprusside: 10-10-10-4 M) vasodilators were assessed using in vitro wire myography. Female offspring from the exercised-trained gilts had a significantly greater endothelium-dependent relaxation response in the thoracic aorta when compared with the male offspring and female offspring from the sedentary gilts. The results of this investigation demonstrate for the first time that maternal exercise during pregnancy produces an enhanced endothelium-dependent vasorelaxation response in the thoracic aortas of female offspring at birth. |
| Databáze: | OpenAIRE |
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