Hematopoietic Stem Cell Transplantation for the Treatment of Autoimmunity in Type 1 Diabetes
| Autor: | Josef Kurtz, Samuel A. LoCascio, Joia Spinelli |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Transplantation Conditioning
T-Lymphocytes medicine.medical_treatment Transplantation Heterologous Medicine (miscellaneous) Autoimmunity Hematopoietic stem cell transplantation medicine.disease_cause Autoantigens Transplantation Autologous Diabetes Mellitus Experimental Transplantation Immunology Animals Humans Medicine Autoimmune disease Type 1 diabetes business.industry Hematopoietic Stem Cell Transplantation Immunosuppression General Medicine medicine.disease Transplantation Diabetes Mellitus Type 1 Immunology Pancreatic islet transplantation business |
| Zdroj: | Current Stem Cell Research & Therapy. 6:29-37 |
| ISSN: | 1574-888X |
| DOI: | 10.2174/157488811794480681 |
| Popis: | Type 1 diabetes (T1D) is an autoimmune disease that leads to the destruction of the insulin-producing pancreatic b cells. While there is no current cure, recent work in the field of allogeneic hematopoietic stem cell transplantation (HSCT) and the induction of mixed chimerism, a state in which multilineage hematopoietic populations of both recipient and donor co-exist, has demonstrated that it is possible to provide protection from disease onset, as well as reverse the autoimmune state in spontaneously diabetic mice. Furthermore, the establishment of mixed chimerism induces donor-specific tolerance, providing the potential to normalize glucose regulation via pancreatic islet transplantation without the requirement of life-long immunosuppression. Current studies are aimed at understanding the mechanisms involved in both the reversal of autoimmunity and the induction of tolerance, with the aim of moving this promising approach to curing T1D into the clinic. |
| Databáze: | OpenAIRE |
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