Integrated contrast-enhanced diagnostic whole-body PET/CT as a first-line restaging modality in patients with suspected metastatic recurrence of breast cancer
| Autor: | Florian Wolf, Mohsen Beheshti, Albert Dirisamer, Daniel Flöry, Marius E. Mayerhoefer, Werner Langsteger, Benjamin S. Halpern |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Contrast Media Breast Neoplasms Sensitivity and Specificity Metastasis Breast cancer Fluorodeoxyglucose F18 Triiodobenzoic Acids medicine Humans Radiology Nuclear Medicine and imaging Whole Body Imaging Aged Neoplasm Staging Aged 80 and over PET-CT business.industry Cancer Reproducibility of Results General Medicine Middle Aged medicine.disease Occult Systems Integration Positron-Emission Tomography Subtraction Technique Female Tomography Breast disease Neoplasm Recurrence Local Radiopharmaceuticals Nuclear medicine business Breast carcinoma Tomography X-Ray Computed |
| Zdroj: | European journal of radiology. 73(2) |
| ISSN: | 1872-7727 |
| Popis: | Objective(s) Only few information exist about the diagnostic accuracy of PET/CT for restaging patients with metastatic recurrence of breast carcinoma. Therefore, our study hypothesis was to perform diagnostic contrast enhanced CT (ce-CT) and FDG-PET in a one-step investigation, to prove sensitivity of each modality and to determine whether diagnostic PET/CT adds information over PET or contrast enhanced CT alone for restaging of patients with suspected recurrence of breast cancer. Methods Fifty-two patients with suspected recurrence of breast cancer were included in our study. All of them were free of metastasis after the first line therapy. Indications for restaging were: Elevated tumor markers n = 32, clinical deterioration n = 16 and/or suspicious findings on other imaging studies n = 48. Integrated PET/CT was performed using contrast-enhanced diagnostic CT for attenuation correction. Results PET was correct in 44/52 patients (85%), ce-CT in 38/52 patients (73%) and PET/CT in 50/52 patients (96%). Sensitivity and specificity of lesion detection of PET, CT and PET/CT were 84%, 66% and 93%, and 100%, 92%, and 100%, respectively. Discussion PET/CT can improve staging and alter therapeutic options in patients suspected to have breast cancer recurrence and distant metastatic disease, primarily by demonstrating local or distant nodal involvement occult at other imaging studies. The added value of FDG-PET/CT over other diagnostic modalities is mainly expressed by the fact that a noninvasive whole-body evaluation is possible in a single examination. |
| Databáze: | OpenAIRE |
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