Role of CaMKII in the regulation of fatty acids and lipid metabolism
| Autor: | Jitcy S. Joseph, Oladapo F. Fagbohun, Sibusiso T Malindisa, Krishnan Anand |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Endocrinology Diabetes and Metabolism Type 2 diabetes 030204 cardiovascular system & hematology Bioinformatics 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Lipid oxidation Ca2+/calmodulin-dependent protein kinase Internal Medicine medicine Animals Humans Obesity Muscle Skeletal Protein kinase A Exercise CAMK Metabolic Syndrome Fatty acid metabolism business.industry Fatty Acids Lipid metabolism General Medicine Lipid Metabolism medicine.disease 030104 developmental biology Diabetes Mellitus Type 2 chemistry Metabolic syndrome Calcium-Calmodulin-Dependent Protein Kinase Type 2 business |
| Zdroj: | Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 15:589-594 |
| ISSN: | 1871-4021 |
| DOI: | 10.1016/j.dsx.2021.02.037 |
| Popis: | Background & aims Previous studies have reported the beneficial roles of the activation of calmodulin-dependent protein kinase (CaMK)II to many cellular functions associated with human health. This review aims at discussing its activation by exercise as well as its roles in the regulation of unsaturated, saturated, omega 3 fatty acids, and lipid metabolism. Methods A wide literature search was conducted using online database such as ‘PubMed’, ‘Google Scholar’, ‘Researcher’, ‘Scopus’ and the website of World Health Organization (WHO) as well as Control Disease and Prevention (CDC). The criteria for the search were mainly lipid and fatty acid metabolism, diabetes, and metabolic syndrome (MetS). A total of ninety-seven articles were included in the review. Results Calmodulin-dependent protein kinase activation by exercise is helpful in controlling membrane lipids related with type 2 diabetes and obesity. CaMKII regulates many health beneficial cellular functions in individuals who exercise compared with those who do not exercise. Regulation of lipid metabolism and fatty acids are crucial in the improvement of metabolic syndrome. Conclusions Approaches that involve CaMKII could be a new avenue for designing novel and effective therapeutic modalities in the treatment or better management of metabolic diseases such as type 2 diabetes and obesity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect