Correlation of histology, human papillomavirus, and viral load in laryngeal papillomas of childhood
| Autor: | Girishwar Sharma, Gerard J. Nuovo, Jonathan DeHart |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
Pathology medicine.medical_specialty In situ hybridization Papillomatosis Pathology and Forensic Medicine law.invention law medicine Humans Papillomaviridae Child Molecular Biology Laryngeal Neoplasms Polymerase chain reaction In Situ Hybridization biology Papilloma Reverse Transcriptase Polymerase Chain Reaction virus diseases Histology Cell Biology Viral Load biology.organism_classification medicine.disease Virology female genital diseases and pregnancy complications Koilocyte Child Preschool DNA Viral Female medicine.symptom Viral load |
| Zdroj: | Diagnostic molecular pathology : the American journal of surgical pathology, part B. 14(4) |
| ISSN: | 1052-9551 |
| Popis: | The purpose of this study was to analyze 47 laryngeal papillomas in children for human papillomavirus (HPV) DNA by in situ hybridization and RT in situ PCR and to correlate these results with the histologic findings. HPV DNA was detected by in situ hybridization in 29 of 47 (62%) of the cases; all positive cases contained HPVs 6 or 11. HPV DNA detection was associated with a statistically significant increase in the presence of keratohyaline granules, nonuniform perinuclear halos, and marked papillomatosis (P |
| Databáze: | OpenAIRE |
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