A New Tiapride Selective Electrode and Its Clinical Application
| Autor: | Mª Soledad García, Concepción Sánchez-Pedreño, M.I. Albero, V. Ródenas, Joaquín A. Ortuño |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Tetraphenylborate
Materials science Ion-selective electrode Analytical chemistry lcsh:Chemical technology iontophoresis solution Biochemistry Atomic and Molecular Physics and Optics Tiapride Electrochemical response Full Research Paper urine Analytical Chemistry Ion selective electrode chemistry.chemical_compound tiapride determination chemistry lcsh:TP1-1185 Electrical and Electronic Engineering Instrumentation Nuclear chemistry |
| Zdroj: | Sensors (Basel, Switzerland) Sensors, Vol 7, Iss 3, Pp 400-409 (2007) Sensors; Volume 7; Issue 3; Pages: 400-409 |
| ISSN: | 1424-8220 |
| Popis: | The construction and electrochemical response characteristics of a poly(vinylchloride) (PVC) membrane selective electrode for the determination of tiapride (TPD) are described. The sensing membrane comprised an ion-pair formed between the protonated drug and tetraphenylborate (TPB-) in a plasticized PVC matrix. The influence of membrane composition on the electrode response was studied. The electrode showed a fast, stable and Nernstian response over a wide tiapride concentration range (1x10-5-1x10-2 M) with a slope of 57.5+/-0.2 mV dec-1 of concentration, a detection limit of 4.3x10-6+/-2.5x10-7 M, a wide working pH range (2-8) and a fast response time (< 5 s). The electrode showed good selectivity towards tiapride with respect to some inorganic and organic compounds. The electrode has been applied to the determination of tiapride in human urine and iontophoresis solution. |
| Databáze: | OpenAIRE |
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