Lean mass as a predictor of bone density and microarchitecture in adult obese individuals with metabolic syndrome
| Autor: | Laura Maria Carvalho de Mendonça, Rodrigo O. Moreira, Thiago Thomaz Mafort, Maria Lucia Fleiuss Farias, Paulo Roberto Alves de Pinho, Agnaldo José Lopes, Eduardo Madeira, Erika Paniago Guedes, Inayá Lima, Miguel Madeira |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male musculoskeletal diseases medicine.medical_specialty Histology Bone density Physiology Endocrinology Diabetes and Metabolism Context (language use) Bone and Bones Bone Density Internal medicine medicine Humans Femur Obesity Quantitative computed tomography Dual-energy X-ray absorptiometry Metabolic Syndrome Bone mineral medicine.diagnostic_test business.industry Organ Size musculoskeletal system Endocrinology Adipose Tissue Multivariate Analysis Body Composition Lean body mass Female Tomography X-Ray Computed business Body mass index |
| Zdroj: | Bone. 59:89-92 |
| ISSN: | 8756-3282 |
| DOI: | 10.1016/j.bone.2013.11.004 |
| Popis: | The effects of obesity and metabolic syndrome (MS) on bone health are controversial. Furthermore, the relationship between body composition and bone quality has not yet been determined in this context. The aim of this study was to investigate the correlations between body composition and bone mineral density (BMD) and bone microstructure in obese individuals with MS. This cross-sectional study assessed 50 obese individuals with MS with respect to their body composition and BMD, both assessed using dual X-ray absorptiometry, and bone microarchitecture, assessed by high-resolution peripheral quantitative computed tomography (HR-pQCT) of the distal tibia and radius. Several HR-pQCT measurements exhibited statistically significant correlations with lean mass. Lean mass was positively correlated with parameters of better bone quality (r: 0.316-0.470) and negatively correlated with parameters of greater bone fragility (r: -0.460 to -0.310). Positive correlations were also observed between lean mass and BMD of the total femur and radius 33%. Fat mass was not significantly correlated with BMD or any HR-pQCT measurements. Our data suggest that lean mass might be a predictor of bone health in obese individuals with MS. |
| Databáze: | OpenAIRE |
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