Tolerability and positive efficacy results after subcutaneous immunotherapy with Parietaria judaica depot extract
| Autor: | Pilar Alba, Ernesto Enrique, Araitz Landeta, María Cruz Gómez-Fernández, Alberto Martínez, Carmen Andreu, Juan Antonio Asturias, Begoña Madariaga-Goirigolzarri, Dolores Hernández Fernández de Rojas, Noelia Colomer, Isabel Flores |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Depot Immunology Infusions Subcutaneous Symptoms score Gastroenterology Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine Subcutaneous immunotherapy Humans Immunology and Allergy Medicine Skin Tests biology Plant Extracts business.industry Rhinitis Allergic Seasonal Respiratory allergy Allergens Antigens Plant Immunoglobulin E Middle Aged biology.organism_classification Rhinitis Allergic Systemic reaction Parietaria 030104 developmental biology 030228 respiratory system Oncology Tolerability Desensitization Immunologic Parietaria judaica Female business |
| Zdroj: | Immunotherapy. 10:1253-1263 |
| ISSN: | 1750-7448 1750-743X |
| DOI: | 10.2217/imt-2018-0051 |
| Popis: | Aim: To evaluate tolerability and efficacy of Parietaria judaica subcutaneous immunotherapy on patients with allergic rhinoconjunctivitis. Patients & methods: 51 patients were assigned to build-up scheme (six increasing doses) of P. judaica depot native extract, plus three maintenance monthly administrations. Results: Out of 470 administered doses, only 3.8% elicited systemic reactions (1.5% nonspecific and 2.3% grade I). Concerning the exploratory efficacy parameters: cutaneous reactivity at the final visit versus baseline was significantly decreased; specific titers of IgG and IgG4 increased significantly and patients showed a significant decrease in the rhinitis symptoms score. Conclusion: P. judaica subcutaneous immunotherapy (Allergovac® depot ROXALL Medicina España S.A., Zamudio, Spain) with an abbreviated up-dosing scheme showed an adequate safety and tolerability profile and induced preliminary efficacy changes. |
| Databáze: | OpenAIRE |
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