Mutational hotspots and conserved domains of SARS-CoV-2 genome in African population
Autor: | Amira Matareek, Olabode E. Omotoso, Ayoade Desmond Babalola |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
viruses
Drug target Pharmaceutical Science Medicine (miscellaneous) Virulence Drug resistance Biology Viral invasion medicine.disease_cause Genome 03 medical and health sciences 0302 clinical medicine Conserved regions medicine lcsh:Science 030304 developmental biology Coronavirus Genetics 0303 health sciences lcsh:R5-920 Transmission (medicine) Host (biology) SARS-CoV-2 Research Outbreak Agricultural and Biological Sciences (miscellaneous) Membrane protein 030220 oncology & carcinogenesis lcsh:Q lcsh:Medicine (General) Vaccine Mutations |
Zdroj: | Beni-Suef University Journal of Basic and Applied Sciences Beni-Suef University Journal of Basic and Applied Sciences, Vol 10, Iss 1, Pp 1-7 (2021) |
ISSN: | 2314-8543 2314-8535 |
Popis: | Background Since outbreak in December 2019, the highly infectious and pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused over a million deaths globally. With increasing burden, the novel coronavirus has posed a dire threat to public health, social interaction, and global economy. Mutations in the SARS-CoV-2 genome are moderately evolving which might have contributed to its genome variability, transmission, replication efficiency, and virulence in different regions of the world. Results The present study elucidated the mutational landscape in the SARS-CoV-2 genome among the African populace, which may have contributed to the virulence, spread, and pathogenicity observed in the region. A total of 3045 SARS-CoV-2 complete protein sequences with the reference viral sequence (EPI_ISL_402124) were mined and analyzed. SARS-CoV-2 ORF1ab, spike, ORF3, ORF8, and nucleocapsid proteins were observed as mutational hotspots in the African population and may be of keen interest in understanding the viral host relationship, while there is conservation in the ORF6, ORF7a, ORF7b, ORF10, envelope, and membrane proteins. Conclusions The accumulation of moderate mutations (though slowly), in the SARS-CoV-2 genome as seen in this present study, could be a promising strategy to develop antiviral drugs or vaccines. These antiviral interventions should target viral conserved domains and host cellular proteins and/or receptors involved in viral invasion and replication to avoid a new viral wave due to drug resistance and vaccine evasion. |
Databáze: | OpenAIRE |
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