Blood‐Catalyzed RAFT Polymerization
| Autor: | Qiang Fu, Shereen Tan, Hadi Ranji-Burachaloo, Greg G. Qiao, Mitchell D. Nothling, Amin Reyhani, Thomas G. McKenzie, Gary Bryant |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Radical polymerization Chain transfer General Medicine 02 engineering and technology General Chemistry Polymer Raft 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences chemistry.chemical_compound chemistry Polymerization Reversible addition−fragmentation chain-transfer polymerization 0210 nano-technology Hydrogen peroxide Macromolecule |
| Zdroj: | Angewandte Chemie International Edition. 57:10288-10292 |
| ISSN: | 1521-3773 1433-7851 |
| Popis: | The use of hemoglobin (Hb) contained within red blood cells to drive a controlled radical polymerization via a reversible addition-fragmentation chain transfer (RAFT) process is reported for the first time. No pre-treatment of the Hb or cells was required prior to their use as polymerization catalysts, indicating the potential for synthetic engineering in complex biological microenvironments without the need for ex vivo techniques. Owing to the naturally occurring prevalence of the reagents employed in the catalytic system (Hb and hydrogen peroxide), this approach may facilitate the development of new strategies for in vivo cell engineering with synthetic macromolecules. |
| Databáze: | OpenAIRE |
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