Neuroimmune Responses Mediate Depression-Related Behaviors following Acute Colitis
| Autor: | Christophe Altier, Lina Chen, Gerald W. Zamponi, Graciela Andonegui, Lilian Basso, Wallace K. MacNaughton, Cristiane Hatsuko Baggio, Zizhen Zhang, Vinicius M. Gadotti, Said M’dahoma, Paul Kubes |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
animal structures Inflammation 02 engineering and technology Behavioral neuroscience Pathophysiology Article Behavioral Neuroscience 03 medical and health sciences Therapeutic approach Medicine Colitis lcsh:Science Depression (differential diagnoses) Acute colitis Multidisciplinary business.industry musculoskeletal neural and ocular physiology fungi Immunity 021001 nanoscience & nanotechnology medicine.disease 3. Good health 030104 developmental biology nervous system Cellular Neuroscience Immunology Major depressive disorder lcsh:Q medicine.symptom 0210 nano-technology business |
| Zdroj: | iScience iScience, Vol 16, Iss, Pp 12-21 (2019) |
| ISSN: | 2589-0042 |
| Popis: | Summary Many patients with visceral inflammation develop pain and psychiatric comorbidities such as major depressive disorder, worsening the quality of life and increasing the risk of suicide. Here we show that neuroimmune activation in mice with dextran sodium sulfate-induced colitis is accompanied by the development of pain and depressive behaviors. Importantly, treatment with the flavonoid luteolin prevented both neuroimmune responses and behavioral abnormalities, suggesting a new potential therapeutic approach for patients with inflammatory bowel diseases. Graphical Abstract Highlights • Acute colitis triggers long-term events related to depression • Leukocytes infiltrate into brain vasculature • Luteolin abolishes leukocyte infiltration and visceral hypersensitivity • Luteolin abolishes depression-related behaviors Pathophysiology; Behavioral Neuroscience; Cellular Neuroscience; Immunity |
| Databáze: | OpenAIRE |
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