Gain of chromosome band 7q11 in papillary thyroid carcinomas of young patients is associated with exposure to low-dose irradiation

Autor:	Gerry Thomas, H. Braselmann, Verena Bauer, Tatjana Bogdanova, Kristian Unger, Horst Zitzelsberger, Johannes Wienberg, Julia Heß
Rok vydání:	2011
Předmět:	Male Candidate gene Neoplasms Radiation-Induced Adolescent DNA Repair DNA repair Physiology Biology medicine.disease_cause Iodine Radioisotopes Young Adult Cell Adhesion medicine Carcinoma Humans FISH post-Chernobyl Thyroid Neoplasms Child In Situ Hybridization Fluorescence Chromosome Aberrations Chromosome 7 (human) Comparative Genomic Hybridization Multidisciplinary Reverse Transcriptase Polymerase Chain Reaction CLDN3 Case-control study Dose-Response Relationship Radiation Biological Sciences medicine.disease Molecular biology Carcinoma Papillary humanities Gene Expression Regulation Neoplastic Chernobyl Nuclear Accident Thyroid Cancer Papillary Case-Control Studies Female Carcinogenesis Microtubule-Associated Proteins Chromosomes Human Pair 7 Comparative genomic hybridization
Zdroj:	Proc. Natl. Acad. Sci. U.S.A. 108, 9595-9600 (2011)
ISSN:	1091-6490 0027-8424
DOI:	10.1073/pnas.1017137108
Popis:	The main consequence of the Chernobyl accident has been an increase in papillary thyroid carcinomas (PTCs) in those exposed to radioactive fallout as young children. Our aim was to identify genomic alterations that are associated with exposure to radiation. We used array comparative genomic hybridization to analyze a main ( n = 52) and a validation cohort ( n = 28) of PTC from patients aged
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5382bad2c4f88a661ba59c4ac0a8a4d https://doi.org/10.1073/pnas.1017137108 Zobrazit plný text záznamu