Prognostic value of late gadolinium enhancement on cardiac magnetic resonance imaging in Japanese hypertrophic cardiomyopathy patients
| Autor: | Morimasa Takayama, Tetsuya Sumiyoshi, Kaori Takada, Haruhiko Machida, Nobuo Iguchi, Yuko Utanohara, Yasuki Hen |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Cardiomyopathy Contrast Media Gadolinium Cardiac magnetic resonance imaging Internal medicine Atrial Fibrillation medicine Animals Humans cardiovascular diseases Aged Retrospective Studies Ejection fraction medicine.diagnostic_test business.industry Hazard ratio Hypertrophic cardiomyopathy Magnetic resonance imaging Atrial fibrillation Stroke Volume General Medicine Stroke volume Cardiomyopathy Hypertrophic Middle Aged medicine.disease Magnetic Resonance Imaging Radiography cardiovascular system Cardiology Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | Circulation journal : official journal of the Japanese Circulation Society. 78(4) |
| ISSN: | 1347-4820 |
| Popis: | Background: The prognostic value of late gadolinium enhancement (LGE) on contrast-enhanced cardiovascular magnetic resonance (CMR) in Japanese hypertrophic cardiomyopathy (HCM) patients in a large, single-center cohort was investigated. Methods and Results: A total of 345 HCM patients (mean age, 59±17 years; 214 male) underwent CMR with gadolinium enhancement, and were followed (mean duration, 21.8 months) for cardiovascular events. Patients were divided into event-positive and event-negative groups. The clinical and CMR characteristics were compared between the 2 groups, and predictors of cardiovascular events assessed on multivariate analysis. LGE was positive in 252 patients (73%). The annual cardiovascular events rate was significantly higher in patients with LGE than in those without (6.2%/year vs. 0.6%/year, P=0.003). On multivariate analysis, LGE (hazard ratio [HR], 7.436; 95% confidence interval [CI]: 1.001–55.228, P=0.050), increased myocardial mass index (HR, 1.013; 95% CI: 1.002–1.023, P=0.018), reduced left ventricular ejection fraction (HR, 0.965; 95% CI: 0.945–0.985, P=0.001), and atrial fibrillation (HR, 2.257; 95% CI: 1.024–4.976, P=0.043) were significantly associated with cardiovascular events. Conclusions: The presence of LGE, increased myocardial mass index, reduced left ventricular ejection fraction and atrial fibrillation were independent predictors of adverse prognosis in Japanese HCM patients. (Circ J 2014; 78: 929–937) |
| Databáze: | OpenAIRE |
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