Opioid system genes in alcoholism: A case–control study in Croatian population
| Autor: | Lipa Čičin-Šain, Jasminka Stefulj, Emilija Zapletal, Jelka Gabrilovac, Tatjana Bordukalo-Niksic, Barbara Čupić, Ana Matošić |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Pro-Opiomelanocortin Adolescent Croatia Population Receptors Opioid mu Single-nucleotide polymorphism Dynorphin Polymorphism Single Nucleotide Young Adult alcohol dependence single nucleotide polymorphism OPRM1 POMC OPRK1 PDYN Cloninger typology Cellular and Molecular Neuroscience Endocrinology Proopiomelanocortin Humans Protein Precursors Allele education Genetic Association Studies Aged Genetic association Genetics education.field_of_study biology Endocrine and Autonomic Systems Receptors Opioid kappa Case-control study Enkephalins General Medicine Middle Aged Genotype frequency Alcoholism Neurology Case-Control Studies biology.protein |
| Zdroj: | Neuropeptides. 47:315-319 |
| ISSN: | 0143-4179 |
| DOI: | 10.1016/j.npep.2013.08.002 |
| Popis: | Due to their involvement in dependence pathways, opioid system genes represent strong candidates for association studies investigating alcoholism. In this study, single nucleotide polymorphisms within the genes for mu (OPRM1) and kappa (OPRK1) opioid receptors and precursors of their ligands - proopiomelanocortin (POMC), coding for beta-endorphin and prodynorphin (PDYN) coding for dynorphins, were analyzed in a case-control study that included 354 male alcohol-dependent and 357 male control subjects from Croatian population. Analysis of allele and genotype frequencies of the selected polymorphisms of the genes OPRM1/POMC and OPRK1/PDYN revealed no differences between the tested groups. The same was true when alcohol-dependent persons were subdivided according to the Cloninger's criteria into type-1 and type-2 groups, known to differ in the extent of genetic control. Thus, the data obtained suggest no association of the selected polymorphisms of the genes OPRM1/POMC and OPRK1/PDYN with alcoholism in Croatian population. |
| Databáze: | OpenAIRE |
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