Synthesis, characterization, thermal properties, antimicrobial evaluation, ADMET study, and molecular docking simulation of new mono Cu (II) and Zn (II) complexes with 2-oxoindole derivatives

Autor:	Ahmed Ragab, Yousry A. Ammar, Ahmed Ezzat, Ammar M. Mahmoud, Mahmoud Basseem I. Mohamed, Abdou S. El-Tabl, Rabie S. Farag
Rok vydání:	2022
Předmět:	Molecular Docking Simulation Thiosemicarbazones Zinc Anti-Infective Agents Spectroscopy Fourier Transform Infrared Health Informatics Microbial Sensitivity Tests Ligands Copper Computer Science Applications Anti-Bacterial Agents
Zdroj:	Computers in biology and medicine. 145
ISSN:	1879-0534
Popis:	One of the interesting research fields is developing and assessing novel metal-containing medications. A new isatin-3-thiosemicarbazone derivative 4 was synthesized by two different methods based on hydrazone derivatives 2 and 3. Additionally, the chelation of thiosemicarbazone with copper (II) and zinc (II) forms a monobasic tridentate (ONS) complex with two five-member rings and a tetrahedral geometry structure. The structure of synthesized complexes was characterized using elemental analysis, FT-IR, mass spectra, and
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c536895ca62ef996a470211e66e3a6f8 https://pubmed.ncbi.nlm.nih.gov/35395516 Zobrazit plný text záznamu Full Text from ScienceDirect