Cytotoxicity of chlorambucil immobilized on magnetic iron oxide nanoparticles Fe 3 O 4
| Autor: | Julia Nowak-Jary, Beata Machnicka, Jacek J. Kozioł |
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| Rok vydání: | 2021 |
| Předmět: |
Chlorambucil
Chemistry Chemical technology Biomedical Engineering Bioengineering TP1-1185 Condensed Matter Physics chemistry.chemical_compound TA401-492 medicine General Materials Science Cytotoxicity Materials of engineering and construction. Mechanics of materials Iron oxide nanoparticles Nuclear chemistry medicine.drug |
| Zdroj: | Micro & Nano Letters, Vol 16, Iss 10, Pp 515-523 (2021) |
| ISSN: | 1750-0443 |
| DOI: | 10.1049/mna2.12080 |
| Popis: | Chlorambucil is a nitrogen mustard alkylating agent used for the treatment of various malignant and non‐malignant cancers. The use of the chemotherapeutic is limited by its toxic side effects which precludes the use of optimal doses. It was decided to investigate if the immobilization of chlorambucil on the magnetic nanoparticles Fe3O4 would increase its cytotoxicity toward chosen cancerous cell lines: ‘Jurkat’ and ‘Hut 78’. The drug was attached to the nanoparticles coated with (3‐aminopropyl)triethoxysilane. The obtained nanostructures were characterized using IR spectroscopy, scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), vibrating sample magnetometer (VSM) and dynamic light scattering (DLS) technic. Zeta‐potential measurements at various pH were also carried out. The drug release studies showed that chlorambucil is released from the nanoparticles surface very effectively. The cytotoxicity studies demonstrated that chlorambucil immobilized on the magnetic nanoparticles Fe3O4 displays significantly higher cytotoxicity in comparison to its unbound form. |
| Databáze: | OpenAIRE |
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