Prospective measurement of blood pressure and heart rate over 24 h in women using combined oral contraceptives with estradiol
| Autor: | Anjeza Xholli, Angelo Cagnacci, Ilaria Piacenti, Giovanni Grandi, Antonella Napolitano, Manuela Bellafronte |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Nomegestrol acetate
Adult medicine.medical_specialty media_common.quotation_subject Population Heart rate Diastole chemistry.chemical_compound Internal medicine medicine Humans Prospective Studies education Menstrual cycle media_common education.field_of_study Estradiol business.industry Dienogest Obstetrics and Gynecology Circadian Rhythm Contraceptives Oral Combined Endocrinology Blood pressure Contraception Reproductive Medicine chemistry Ambulatory Female business |
| Popis: | Objective Combined oral contraceptives (COCs) containing ethinyl-estradiol are known to increase blood pressure (BP). We evaluated whether COCs containing estradiol (E2) influence 24-h ambulatory BP and heart rate (HR) in normotensive and normal-weight women. Study design Twenty-four-hour BP and HR were measured every 30 min with an ambulatory BP device in 18 normotensive healthy non-smoking women prior to (Days 3–6 of menstrual cycle) and after 6 months of use (Days 20–24 of cycle 6) of a COC containing either a quadriphasic combination of E2 valerate plus dienogest ( n =11) or a monophasic association of micronized E2 plus nomegestrol acetate ( n =7). Results Mean age and body mass index of the final sample were 32.50±7.49 years and 22.87±4.08, respectively. E2-based COCs induced no modification of 24-h systolic BP (+1.65±8.34 mmHg; p=.41), diastolic BP (+0.04±7.36 mmHg; p=.98), mean BP (+0.64±6.42 mmHg; p=.68) or HR (−0.72±5.86 beats/min; p=.61). Differences were not observed even when daytime or nighttime values were separately considered. Though this was not a comparative study, we did not find differences between the effects of the two formulations (24-h mean BP; p=.699). Conclusions These data suggest a neutral effect of estradiol-based COCs on independent risk factors for cardiovascular diseases such as BP or HR. Implications BP and HR of normotensive women are not increased by E2-based COCs. |
| Databáze: | OpenAIRE |
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