Characterizing the white matter hyperintensity penumbra with cerebral blood flow measures
| Autor: | William D. Rooney, J. A. Kaye, Nutta-on Promjunyakul, David Lahna, Lisa C. Silbert, Hiroko H. Dodge, Deniz Erten-Lyons |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Aging WMH white matter hyperintensity Vascular dementia lcsh:RC346-429 030218 nuclear medicine & medical imaging M0 the initial ASL datasets 0302 clinical medicine PASL pulsed arterial spin labeling DWMH deep white matter hyperintensity Aged 80 and over NAWM L1 normal appearing white matter layer 1 medicine.diagnostic_test Penumbra White matter hyperintensity (WMH) Magnetic Resonance Imaging White Matter 3. Good health medicine.anatomical_structure Neurology Cerebral blood flow Cerebrovascular Circulation NAWM normal appearing white matter Cardiology lcsh:R858-859.7 Female PCASL pseudo-continuous arterial spin labeling CBF cerebral blood flow Psychology Arterial spin labeling (ASL) medicine.medical_specialty NAWM L15 normal appearing white matter layer 15 Cognitive Neuroscience PVWMH periventricular white matter hyperintensity CASL continuous arterial spin labeling lcsh:Computer applications to medicine. Medical informatics behavioral disciplines and activities Article White matter 03 medical and health sciences Cognitive aging Internal medicine mental disorders Cerebral blood flow (CBF) penumbra medicine Humans Radiology Nuclear Medicine and imaging CBF - Cerebral blood flow lcsh:Neurology. Diseases of the nervous system Aged Magnetic resonance imaging medicine.disease Hyperintensity White matter hyperintensity Spin Labels Neurology (clinical) Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage: Clinical, Vol 8, Iss C, Pp 224-229 (2015) NeuroImage : Clinical |
| ISSN: | 2213-1582 |
| Popis: | Objective White matter hyperintensities (WMHs) are common with age, grow over time, and are associated with cognitive and motor impairments. Mechanisms underlying WMH growth are unclear. We aimed to determine the presence and extent of decreased normal appearing white matter (NAWM) cerebral blood flow (CBF) surrounding WMHs to identify ‘WM at risk’, or the WMH CBF penumbra. We aimed to further validate cross-sectional finding by determining whether the baseline WMH penumbra CBF predicts the development of new WMHs at follow-up. Methods Sixty-one cognitively intact elderly subjects received 3 T MPRAGE, FLAIR, and pulsed arterial spin labeling (PASL). Twenty-four subjects returned for follow-up MRI. The inter-scan interval was 18 months. A NAWM layer mask, comprised of fifteen layers, 1 mm thick each surrounding WMHs, was generated for periventricular (PVWMH) and deep (DWMH) WMHs. Mean CBF for each layer was computed. New WMH and persistent NAWM voxels for each penumbra layer were defined from follow-up MRI. Results CBF in the area surrounding WMHs was significantly lower than the total brain NAWM, extending approximately 12 mm from both the established PVWMH and DWMH. Voxels with new WMH at follow-up had significantly lower baseline CBF than voxels that maintained NAWM, suggesting that baseline CBF can predict the development of new WMHs over time. Conclusions A CBF penumbra exists surrounding WMHs, which is associated with future WMH expansion. ASL MRI can be used to monitor interventions to increase white matter blood flow for the prevention of further WM damage and its cognitive and motor consequences. Highlights • We examined cerebral blood flow (CBF) surrounding white matter hyperintensity (WMH) lesions. • We examined whether low baseline CBF is associated with WMH expansion over time. • WMH CBF penumbra exists, extending ~12 mm from both periventricular and deep WMH lesions. • Baseline CBF can predict the development of new WMHs over time. • ASL MRI can be used to monitor interventions to increase white matter blood flow. |
| Databáze: | OpenAIRE |
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