Utilize lung ultrasound B-lines and KL-6 to monitor anti-MDA-5 antibody-positive clinically amyopathic dermatomyositis-associated interstitial lung disease: a case report and literature review
Autor: | Qisheng Lin, Xiufeng Huang, Jianqun Lin, Shaoqi Chen, Zhangzhang Lin, Yukai Wang, Guangzhou Du, Marco Matucci-Cerinic, Daniel E. Furst, Xuezhen Xie |
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Rok vydání: | 2019 |
Předmět: |
Adult
medicine.medical_specialty Pathology Interferon-Induced Helicase IFIH1 Cyclophosphamide Connective tissue Dermatomyositis Pulmonary function testing 03 medical and health sciences 0302 clinical medicine Rheumatology Internal medicine medicine Humans 030212 general & internal medicine Lung Ultrasonography 030203 arthritis & rheumatology business.industry Mucin-1 Interstitial lung disease General Medicine Pirfenidone respiratory system medicine.disease respiratory tract diseases Respiratory Function Tests medicine.anatomical_structure Methylprednisolone Antibodies Antinuclear Disease Progression Female business Lung Diseases Interstitial Biomarkers medicine.drug |
Zdroj: | Clinical rheumatology. 38(5) |
ISSN: | 1434-9949 |
Popis: | In the past decade, lung ultrasound (LUS) B-lines and serum Krebs von den Lungen-6 (KL-6) antigen have been recognized as biomarkers of the connective tissue disease-associated interstitial lung diseases (CTD-ILDs). Robust data have demonstrated that B-lines total numbers and KL-6 levels are correlated with high-resolution computed tomography findings, pulmonary function test, and some clinical parameters in CTD-ILDs. However, limited data are available regarding the use of these two biomarkers to follow CTD-ILDs. Herein, we report a case with anti-melanoma differentiation-associated gene 5 antibody-positive clinically amyopathic dermatomyositis-associated ILD, successfully treated with high-dose methylprednisolone, cyclophosphamide, intravenous immunoglobulin, pirfenidone, and followed using lung ultrasound and KL-6. |
Databáze: | OpenAIRE |
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