Failure of transferrin to enhance iron absorption in achlorhydric human subjects
| Autor: | D. P. Derman, Thomas H. Bothwell, Werner R. Bezwoda, R. D. Baynes, A P MacPhail, J. D. Torrance |
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| Rok vydání: | 1986 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Chemistry Stomach Achlorhydria Iron Transferrin Hematology Metabolism Absorption (skin) medicine.disease Ferrous Pernicious anaemia Endocrinology medicine.anatomical_structure Intestinal Absorption Internal medicine Anemia Pernicious medicine Ferric Humans medicine.drug |
| Zdroj: | British journal of haematology. 63(4) |
| ISSN: | 0007-1048 |
| Popis: | Summary There is evidence in experimental animals that transferrin, produced either by gastrointestinal cells or derived from bile, mediates the luminal absorption of iron. The applicability of these findings to human subjects was tested by administering diferric transferrin labelled with 3 mg 59Fe to seven patients with pernicious anaemia. Achlorhydric subjects were chosen to ensure that the iron transferrin complex did not dissociate in the stomach. The geometric mean absorption of 1.4% was similar to that of 3 mg iron given as ferric chloride (1.9%) and much less than that of ferrous ascorbate (18.9%). These findings suggest that transferrin does not play a physiological role in the absorption of iron in human subjects. |
| Databáze: | OpenAIRE |
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