A new perspective for advanced positron emission tomography-based molecular imaging in neurodegenerative proteinopathies

Autor: Juha Rinne, Francisco R. López-Picón, Elena Rodriguez-Vieitez, Rainer Hinz, Leonardo Iaccarino, Rosa Maria Moresco, Agneta Nordberg, Marie Joao Santiago-Ribeiro, Alexander Gerhard, Gitte M. Knudsen, Karl Herholz, Albert D. Windhorst, Matthias M. Herth, Adriaan A. Lammertsma, Johnny Vercouillie, Sabina Pappatà, Christer Halldin, Oskar Hansson, David J. Brooks, Anthony Gee, Koen Van Laere, Bertrand Kuhnast, Ronald Boellaard, Michel Bottlaender, Federico Turkheimer, Andrea Varrone, Alexandra Winkeler, Sylvie Chalon, Andreas H. Jacobs, Daniela Perani, Michael A. Carroll, Paul Edison
Přispěvatelé: Radiology and nuclear medicine, Amsterdam Neuroscience - Brain Imaging, ACS - Heart failure & arrhythmias, ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Chalon, Sylvie, VU University Medical Center [Amsterdam], Univ Groningen, Univ Med Ctr Groningen, Lund University [Lund], Perani, D, Iaccarino, L, Lammertsma, Aa, Windhorst, Ad, Edison, P, Boellaard, R, Hansson, O, Nordberg, A, Jacobs, A, on behalf of all partners of the IMBI, Project, Lammertsma, A, Windhorst, A, Bottlaender, M, Brooks, D, Carroll, M, Chalon, S, Gee, A, Gerhard, A, Halldin, C, Herholz, K, Herth, M, Hinz, R, Knudsen, G, Kuhnast, B, Lopez-Picon, F, Moresco, R, Pappata, S, Rinne, J, Rodriguez-Vieitez, E, Santiago-Ribeiro, M, Turkheimer, F, Van Laere, K, Varrone, A, Vercouillie, J, Winkeler, A
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
18-KDA TRANSLOCATOR PROTEIN
MILD COGNITIVE IMPAIRMENT
Epidemiology
PET TRACER F-18-AV-1451
[SDV]Life Sciences [q-bio]
Diagnostic tools
Abnormal protein
AMYOTROPHIC-LATERAL-SCLEROSIS
chemistry.chemical_compound
0302 clinical medicine
Neuroinflammation
Medicine
TAU-PET
ComputingMilieux_MISCELLANEOUS
IN-VIVO
medicine.diagnostic_test
Health Policy
Amyloid
Neuroinflammation
PET molecular imaging
Protheinopathies
Radiotracers
Tau
Neurodegenerative Diseases
Frontotemporal lobar degeneration
ALZHEIMERS ASSOCIATION WORKGROUPS
3. Good health
[SDV] Life Sciences [q-bio]
Psychiatry and Mental health
Radiotracers
Positron emission tomography
Protheinopathie
Specific protein
Amyloid
PET molecular imaging
Neuroimaging
Neuropathology
CEREBRAL AMYLOID ANGIOPATHY
03 medical and health sciences
Cellular and Molecular Neuroscience
Developmental Neuroscience
Humans
Proteostasis Deficiencies
FRONTOTEMPORAL LOBAR DEGENERATION
Radiotracer
business.industry
PITTSBURGH COMPOUND-B
medicine.disease
030104 developmental biology
chemistry
Positron-Emission Tomography
Protheinopathies
Neurology (clinical)
Geriatrics and Gerontology
Molecular imaging
Tau
business
Pittsburgh compound B
Neuroscience
030217 neurology & neurosurgery
Zdroj: Perani, D, Iaccarino, L, Lammertsma, A A, Windhorst, A D, Edison, P, Boellaard, R, Hansson, O, Nordberg, A, Jacobs, A H & IMBI Project 2019, ' A new perspective for advanced positron emission tomography–based molecular imaging in neurodegenerative proteinopathies ', Alzheimer's and Dementia, vol. 15, no. 8, pp. 1081-1103 . https://doi.org/10.1016/j.jalz.2019.02.004
Alzheimer's and Dementia, 15(8), 1081-1103. Elsevier
Perani, D, Iaccarino, L, Lammertsma, A A, Windhorst, A D, Edison, P, Boellaard, R, Hansson, O, Nordberg, A, Jacobs, A H & Partners IMBI Project 2019, ' A new perspective for advanced positron emission tomography-based molecular imaging in neurodegenerative proteinopathies ', Alzheimer's & Dementia, vol. 15, no. 8, pp. 1081-1103 . https://doi.org/10.1016/j.jalz.2019.02.004
Alzheimers & dementia, 15(8), 1081-1103. ELSEVIER SCIENCE INC
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Wiley, 2019, 15 (8), pp.1081-1103. ⟨10.1016/j.jalz.2019.02.004⟩
ISSN: 1552-5260
2352-8729
DOI: 10.1016/j.jalz.2019.02.004
Popis: Recent studies in neurodegenerative conditions have increasingly highlighted that the same neuropathology can trigger different clinical phenotypes or, vice-versa, that similar phenotypes can be triggered by different neuropathologies. This evidence has called for the adoption of a pathology spectrum-based approach to study neurodegenerative proteinopathies. These conditions share brain deposition of abnormal protein aggregates, leading to aberrant biochemical, metabolic, functional, and structural changes. Positron emission tomography (PET) is a well-recognized and unique tool for the in vivo assessment of brain neuropathology, and novel PET techniques are emerging for the study of specific protein species. Today, key applications of PET range from early research and clinical diagnostic tools to their use in clinical trials for both participants screening and outcome evaluation. This position article critically reviews the role of distinct PET molecular tracers for different neurodegenerative proteinopathies, highlighting their strengths, weaknesses, and opportunities, with special emphasis on methodological challenges and future applications. (C) 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
Databáze: OpenAIRE
Externí odkaz: