Reelin controls progenitor cell migration in the healty and pathological adult brain

Autor: Lluís Pujadas, Eduardo Soriano, Karine Magalon, Myriam Cayre, Harold Cremer, Pascale Durbec, Julien Vernerey, Sandrine Courtès
Přispěvatelé: Universitat de Barcelona
Předmět:
Male
Neurobiologia del desenvolupament
Rostral migratory stream
lcsh:Medicine
Cerebral Ventricles
Mice
Neural Stem Cells
Cell Movement
Molecular Cell Biology
Neurobiology of Disease and Regeneration
Reelin
Developmental neurobiology
lcsh:Science
Extracellular Matrix Proteins
Multidisciplinary
Neuronal Morphology
Stem Cells
Serine Endopeptidases
Brain
Cell migration
DAB1
Neural stem cell
Up-Regulation
Extracellular Matrix
Health
medicine.symptom
Hippocampus (Brain)
Signal Transduction
Research Article
Cell Adhesion Molecules
Neuronal
Neurogenesis
Hipocamp (Cervell)
Mice
Transgenic
Nerve Tissue Proteins
Brain damage
Biology
Prosencephalon
Developmental Neuroscience
Neuroglial Development
medicine
Animals
Humans
Progenitor cell
Extracellular Matrix Adhesions
Progenitor
lcsh:R
Reelin Protein
HEK293 Cells
nervous system
Cellular Neuroscience
Immunology
biology.protein
lcsh:Q
Neuroscience
Demyelinating Diseases
Zdroj: Recercat. Dipósit de la Recerca de Catalunya
instname
PLoS ONE
Dipòsit Digital de la UB
Universidad de Barcelona
PLoS ONE, Vol 6, Iss 5, p e20430 (2011)
Popis: Understanding the signals that control migration of neural progenitor cells in the adult brain may provide new therapeutic opportunities. Reelin is best known for its role in regulating cell migration during brain development, but we now demonstrate a novel function for reelin in the injured adult brain. First, we show that Reelin is upregulated around lesions. Second, experimentally increasing Reelin expression levels in healthy mouse brain leads to a change in the migratory behavior of subventricular zone-derived progenitors, triggering them to leave the rostral migratory stream (RMS) to which they are normally restricted during their migration to the olfactory bulb. Third, we reveal that Reelin increases endogenous progenitor cell dispersal in periventricular structures independently of any chemoattraction but via cell detachment and chemokinetic action, and thereby potentiates spontaneous cell recruitment to demyelination lesions in the corpus callosum. Conversely, animals lacking Reelin signaling exhibit reduced endogenous progenitor recruitment at the lesion site. Altogether, these results demonstrate that beyond its known role during brain development, Reelin is a key player in post-lesional cell migration in the adult brain. Finally our findings provide proof of concept that allowing progenitors to escape from the RMS is a potential therapeutic approach to promote myelin repair.
Databáze: OpenAIRE
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