Relationship between plasma levels of cardiac natriuretic peptides and soluble Fas: plasma soluble Fas as a prognostic predictor in patients with congestive heart failure
| Autor: | Masahiko Kinoshita, Takayoshi Tsutamoto, Takashi Tsutsui, Takashi Yamamoto, Atsuyuki Wada, Masaru Hayashi, Tomoyuki Takayama, Masanori Fujii, Masato Ohnishi, Takehiro Matsumoto, Naoko Mabuchi, Keiko Maeda |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Apoptosis Severity of Illness Index Pathogenesis Norepinephrine Atrial natriuretic peptide Japan Predictive Value of Tests Internal medicine Natriuretic Peptide Brain Natriuretic peptide Medicine Humans cardiovascular diseases fas Receptor Aged Heart Failure Ejection fraction Endothelin-1 business.industry Tumor Necrosis Factor-alpha Age Factors Stroke Volume Stroke volume Middle Aged Brain natriuretic peptide medicine.disease Prognosis Endothelin 1 Survival Analysis Endocrinology Solubility Heart failure cardiovascular system Cardiology Female Cardiology and Cardiovascular Medicine business Atrial Natriuretic Factor Biomarkers circulatory and respiratory physiology Follow-Up Studies |
| Zdroj: | Journal of cardiac failure. 7(4) |
| ISSN: | 1071-9164 |
| Popis: | Background: Cardiac natriuretic peptides may induce apoptosis in myocytes; however, the relationship between plasma levels of cardiac natriuretic peptides and those of soluble Fas (sFas) and tumor necrosis factor (TNF)-α remains unknown in patients with congestive heart failure (CHF). Methods and Results: We measured plasma levels of sFas and TNF-α and those of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), norepinephrine, and endothelin 1 in 96 patients with CHF (ejection fraction < 45%). The patients were monitored for 3 years. Plasma levels of sFas and TNF-α increased with the severity of CHF. There was no significant correlation between sFas plasma levels and those of ANP and BNP. Cox proportional hazard analysis showed that high levels of sFas (P =.009) and BNP (P |
| Databáze: | OpenAIRE |
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