Responses of neurologic complications of AIDS to 3'-azido-3'-deoxythymidine and 9-(1,3-dihydroxy-2-propoxymethyl) guanine. I. Clinical features
| Autor: | Keith Williams, Domenic Casareale, Milan Fiala, Norman Cohen, Lawrence A. Cone, Wallace Tourtelotte, Paul Shapshak, Dinesh Patel |
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| Rok vydání: | 1988 |
| Předmět: |
Microbiology (medical)
Ganciclovir Adult Male medicine.medical_specialty Eye Diseases Encephalopathy Retinitis Acyclovir Gastroenterology Antiviral Agents Central Nervous System Diseases Meningoencephalitis Internal medicine Medicine Humans Acquired Immunodeficiency Syndrome business.industry virus diseases Polyradiculoneuropathy medicine.disease Magnetic Resonance Imaging Infectious Diseases Immunology Acute Disease Cytomegalovirus retinitis business Polyneuropathy Zidovudine Encephalitis medicine.drug Thymidine |
| Zdroj: | Reviews of infectious diseases. 10(2) |
| ISSN: | 0162-0886 |
| Popis: | Fourteen patients with AIDS were treated for 23 neurologic complications: four episodes of acute meningoencephalitis; eight episodes of subacute encephalopathy; two cases of progressive multifocal leukoencephalopathy; and nine cases of polyneuropathy. Nine patients were treated with 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG), one with 3'-azido-3'-deoxythymidine (AZT), and four initially with DHPG directed against cytomegalovirus (CMV) retinitis or encephalitis and subsequently with AZT against human immunodeficiency virus (HIV) encephalopathy. CMV retinitis was a helpful clinical observation indicating neurologic involvement. DHPG produced improvement in two of three cases of acute meningoencephalitis but was ineffective in cases of subacute encephalopathy or neuropathy. AZT therapy resulted in resolution in both of the two treated cases of acute confusional state and in two of the four treated cases of polyradiculoneuropathy with paraparesis but was ineffective in the late stage of subacute encephalopathy. These results suggest that CMV is important in some cases of acute meningoencephalitis, whereas HIV is a dominant pathogen in subacute dementia and polyneuropathy in patients with AIDS. DHPG may be beneficial in the former, whereas AZT appears to be effective in the latter complications. Human immunodeficiency virus (HIV) has been im |
| Databáze: | OpenAIRE |
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