Comparison of efficacy in adjuvant chemotherapy regimens in patients with radically resected gastric cancer: a propensity-matched analysis
| Autor: | Yi Feng Liao, Hongtao Chen, Ren Cui Quan, Da Zhi Xu, Wei Ze Lv, Jianjun Liu, Nan Chen, Hongyu Zhang, Jia Xing Huang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Subgroup analysis Kaplan-Meier Estimate radically resected 03 medical and health sciences Young Adult 0302 clinical medicine Gastrectomy Stomach Neoplasms Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans 030212 general & internal medicine Stage (cooking) Young adult Aged Neoplasm Staging Retrospective Studies Aged 80 and over business.industry gastric cancer Hazard ratio Cancer Retrospective cohort study Middle Aged medicine.disease Combined Modality Therapy Surgery adjuvant chemotherapy Treatment Outcome Oncology Chemotherapy Adjuvant 030220 oncology & carcinogenesis Propensity score matching Female Clinical Research Paper Neoplasm Grading business Follow-Up Studies |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // RenCui Quan 1, * , JiaXing Huang 1, * , HongTao Chen 2, * , YiFeng Liao 1 , WeiZe Lv 1 , Nan Chen 1 , JianJun Liu 3, 4 , HongYu Zhang 1 , DaZhi Xu 3, 4 1 Department of Medical Oncology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhu Hai, Guangdong Province, People’s Republic of China 2 Department of Laboratory, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhu Hai, Guangdong Province, People’s Republic of China 3 Department of Gastric and Pancreatic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong Province, China 4 State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong Province, China * These authors have contributed equally to this work Correspondence to: HongYu Zhang, email: zdwyzhy@163.com DaZhi Xu, email: xudzh@sysucc.org.cn Keywords: adjuvant chemotherapy, radically resected, gastric cancer Received: February 20, 2016 Accepted: August 09, 2016 Published: September 01, 2016 ABSTRACT Background: We conducted the retrospective study to compare the efficacy of monotherapies versus two-drug regimens as postoperative chemotherapy for patients with radically resected gastric cancer. Result: At a median follow-up of 5.3 years, no significant difference in terms of OS was observed between two groups, neither before nor after matching. After matching, median DFS was statistically significant between group A and B (median, 67.5 vs 101.0 months, respectively; hazard ratio [HR], 0.65; 95% CI, 0.45 to 0.95; P =0.027), which meant doublets prolonged DFS. In subgroup analysis, the patients of stage III receiving doublet achieved better OS than those receiving monotherapy. People who received doublet and were less than 65 years old, or male patients, or in T4 stage, or in N2 stage, or receiving subtotal gastrectomy had better DFS than those with monotherapy. Method: A data set including 501 patients (monotherapy, n=107; doublet, n=394) was matched between the two groups (n=107 patients per group) using the propensity-matched study. The primary and secondary endpoint was overall survival(OS) and disease-free survival(DFS), respectively. Survival data was compared using the Kaplan-Meier method and Cox proportion hazards models for univariate and multivariate analyses. Conclusion: The dual regimens seemed not to add overall survival benefits to patients receiving curative gastrectomy, compared with single-agent fluoropyrimidine as postoperative chemotherapy. However, dual regimens showed better disease-free survival. |
| Databáze: | OpenAIRE |
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