Stress modulation of the memory retrograde-enhancing effects of the awakening drug modafinil in mice
| Autor: | Christophe Tronche, Jean-Claude Jouanin, Daniel Béracochéa, Frédéric Chauveau, Pierrette Liscia, Christophe Piérard |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Drug medicine.medical_specialty media_common.quotation_subject medicine.medical_treatment Modafinil Context (language use) Serial Learning Discrimination Learning Mice chemistry.chemical_compound Corticosterone Orientation Internal medicine mental disorders medicine Animals Benzhydryl Compounds media_common Pharmacology Appetitive Behavior Dose-Response Relationship Drug Memoria Association Learning Retention Psychology Mice Inbred C57BL Steroid hormone Treatment Outcome Endocrinology chemistry Mental Recall Central Nervous System Stimulants Cues Arousal Contextual memory Psychology Injections Intraperitoneal Stress Psychological Glucocorticoid medicine.drug |
| Zdroj: | Psychopharmacology. 196:1-13 |
| ISSN: | 1432-2072 0033-3158 |
| DOI: | 10.1007/s00213-007-0915-8 |
| Popis: | This study investigated the dose-effect relationship of modafinil administration on contextual memory processes, in parallel with the measurements of plasma corticosterone levels in acutely stressed mice.Memory was first evaluated in normal (nonstressed) mice either in contextual (CSD) or spatial (SSD) tasks. Thus, C57 Bl/6 Jico mice learned two consecutive discriminations (D1 and D2) in a four-hole board. The discriminations occurred on either distinct (CSD) or identical (SSD) floors (internal contextual cues). All mice received a vehicle intraperitoneal injection before learning and were injected 24 h later (20 min before the test session) either with vehicle or modafinil.Results showed that modafinil-treated mice behaved similarly as vehicles in the spatial SSD task, whereas in contrast, memory of the first-learned discrimination (D1) in the CSD task was enhanced by a 32- but not a 16-mg/kg modafinil dose. Hence, we studied the effect of a pretest acute stress (electric footshocks) specifically on D1 performance in modafinil-treated subjects. Immediately after behavioral testing, blood was sampled to measure plasma corticosterone levels.Results showed that: (1) stress significantly improved performance in vehicles, (2) stress decreased the efficiency threshold of modafinil, as performance was enhanced at the low dose (16 mg/kg), whereas this enhancement was obtained for the high dose (32 mg/kg) under nonstress conditions, (3) the performance was impaired at the high (32 mg/kg) dose, and (4) modafinil significantly reduced the magnitude of the stress-induced corticosterone secretion, mainly at the dose of 32 mg/kg. |
| Databáze: | OpenAIRE |
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