Structural basis of signal-sequence recognition by the signal recognition particle
| Autor: | Gitte Meriläinen, Kristoffer Brännström, Shenghua Huang, Tobias Hainzl, A. Elisabeth Sauer-Eriksson |
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| Rok vydání: | 2011 |
| Předmět: |
Models
Molecular Signal peptide Signal recognition particle Base Sequence Basis (linear algebra) Archaeal Proteins Methanococcus Molecular Sequence Data Plasma protein binding Protein Sorting Signals Biology Crystallography X-Ray environment and public health Ribosome Crystallography Structural Biology Base sequence Biological system Signal Recognition Particle Molecular Biology Signal recognition particle receptor Protein Binding |
| Zdroj: | Nature Structural & Molecular Biology. 18:389-391 |
| ISSN: | 1545-9985 1545-9993 |
| DOI: | 10.1038/nsmb.1994 |
| Popis: | The signal recognition particle (SRP) recognizes and binds the signal sequence of nascent proteins as they emerge from the ribosome. We present here the 3.0-Å structure of a signal sequence bound to the Methanococcus jannaschii SRP core. Structural comparison with the free SRP core shows that signal-sequence binding induces formation of the GM-linker helix and a 180° flip of the NG domain-structural changes that ensure a hierarchical succession of events during protein targeting. |
| Databáze: | OpenAIRE |
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