Focus on the glycerophosphocholine pathway in choline phospholipid metabolism of cancer
| Autor: | Ruoqing Cai, Oluwatobi Adelaja, Menglin Cheng, Kristine Glunde, Caitlin M. Tressler, Vinay Ayyappan, Kanchan Sonkar |
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| Rok vydání: | 2019 |
| Předmět: |
Phospholipid
medicine.disease_cause Article Choline Substrate Specificity 030218 nuclear medicine & medical imaging 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Neoplasms Phosphatidylcholine medicine Animals Humans Radiology Nuclear Medicine and imaging Spectroscopy Phosphocholine Cancer Metabolism medicine.disease Glycerylphosphorylcholine chemistry Biochemistry Tumor progression Molecular Medicine Carcinogenesis Metabolic Networks and Pathways 030217 neurology & neurosurgery Transcription Factors |
| Zdroj: | NMR Biomed |
| ISSN: | 1099-1492 0952-3480 |
| DOI: | 10.1002/nbm.4112 |
| Popis: | Activated choline metabolism is a hallmark of carcinogenesis and tumor progression, which leads to elevated levels of phosphocholine and glycerophosphocholine in all types of cancer tested so far. Magnetic resonance spectroscopy applications have played a key role in detecting these elevated choline phospholipid metabolites. To date, the majority of cancer-related studies has focused on phosphocholine and the Kennedy pathway, which constitutes the biosynthesis pathway for membrane phosphatidylcholine. Fewer and more recent studies have reported on the importance of glycerophosphocholine in cancer. In this review article, we are summarizing the recent literature on glycerophosphocholine metabolism with respect to its cancer biology and its detection by magnetic resonance spectroscopy applications. |
| Databáze: | OpenAIRE |
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