An epidemiology report for primary central nervous system tumors in adolescents and young adults: a nationwide population-based study in France, 2008–2013
| Autor: | Luc Bauchet, Didier Frappaz, Valérie Rigau, Johan Pallud, Brigitte Trétarre, Amélie Darlix, Sam Ng, Sonia Zouaoui, Faiza Bessaoud, Hélène Mathieu-Daudé, Thomas Roujeau, Alexandre Roux, Dominique Figarella-Branger, Fabienne Bauchet |
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| Přispěvatelé: | Department of Biomolecular Engineering, University of California [Santa Cruz] (UC Santa Cruz), University of California (UC)-University of California (UC), UNICANCER - Institut régional du Cancer Montpellier Val d'Aurelle (ICM), CRLCC Val d'Aurelle - Paul Lamarque, Institut des Neurosciences de Montpellier (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Service de santé publique [Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Service d'épidémiologie, Groupe de neuro-oncologie du Languedoc Roussillon, FRANCIM, Réseau des registres français du cancer, Institut de neurophysiopathologie (INP), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Service d’Anatomie Pathologique et de Neuropathologie, APHM, Hôpital de la Timone, Hôpital de la Timone [CHU - APHM] (TIMONE), Aix Marseille Université (AMU), Centre Hospitalier Sainte Anne [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Surgical oncology Centre Léon Bérard, Centre Léon Bérard [Lyon], Service de Neurochirurgie [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-CHU Gui de Chauliac [Montpellier], Neurochirurgie [Hôpital Gui de Chauliac], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier], University of California [Santa Cruz] (UCSC), University of California-University of California, Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), Service de Neurochirurgie [CHRU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [CHU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier) |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Cancer Research Pediatrics medicine.medical_specialty Adolescent [SDV]Life Sciences [q-bio] Population Brain tumor Neuropathology Central Nervous System Neoplasms Young Adult 03 medical and health sciences Age Distribution 0302 clinical medicine Biopsy Epidemiology medicine Humans Young adult education ComputingMilieux_MISCELLANEOUS education.field_of_study medicine.diagnostic_test Brain Neoplasms business.industry Incidence Editorials Histology medicine.disease 3. Good health Europe Oncology 030220 oncology & carcinogenesis Female France Neurology (clinical) Neurosurgery business 030217 neurology & neurosurgery |
| Zdroj: | Neuro-Oncology Neuro-Oncology, 2019, ⟨10.1093/neuonc/noz227⟩ Neuro Oncol Neuro-Oncology, Oxford University Press (OUP), 2019, ⟨10.1093/neuonc/noz227⟩ |
| ISSN: | 1523-5866 1522-8517 |
| DOI: | 10.1093/neuonc/noz227 |
| Popis: | Background Primary central nervous system tumors (PCNST) among adolescents and young adults (AYA, 15–39 y) have rarely been reported. We present a nationwide report of PCNST histologically confirmed in the French AYA population between 2008 and 2013. Methods Patients were identified through the French Brain Tumor Database (FBTDB), a national dataset that includes prospectively all histologically confirmed cases of PCNST in France. Patients aged 15 to 39 years with histologically confirmed PCNST diagnosed between 2008 and 2013 were included. For each of the 143 histological subtypes of PCNST, crude rates, sex, surgery, and age distribution were provided. To enable international comparisons, age-standardized incidence rates were adjusted to the world-standard, European, and USA populations. Results For 6 years, 9661 PCNST (males/females: 4701/4960) were histologically confirmed in the French AYA population. The overall crude rate was 8.15 per 100 000 person-years. Overall, age-standardized incidence rates were (per 100 000 person-years, population of reference: world/Europe/USA): 7.64/8.07/8.21, respectively. Among patients aged 15–24 years, the crude rate was 5.13 per 100 000. Among patients aged 25–39 years, the crude rate was 10.10 per 100 000. Age-standardized incidence rates were reported for each of the 143 histological subtypes. Moreover, for each histological subtype, data were detailed by sex, age, type of surgery (surgical resection or biopsy), and cryopreserved samples. Conclusion These data represent an exhaustive report of all histologically confirmed cases of PCNST with their frequency and distribution in the French AYA population in 2008–2013. For the first time in this age group, complete histological subtypes and rare tumor identification are detailed. |
| Databáze: | OpenAIRE |
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