A cross-sectional comparison of persons with syncytium- and non-syncytium-inducing human immunodeficiency virus
| Autor: | Stephen A. Spector, Brian Wright, Richman Dd, Samuel A. Bozzette, McCutchan Ja |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male viruses HIV Core Protein p24 Cell Count HIV Infections Biology Giant Cells Virus Cohort Studies Acquired immunodeficiency syndrome (AIDS) Immunity Immunopathology medicine Immunology and Allergy Humans Sida Syncytium Analysis of Variance virus diseases HIV medicine.disease biology.organism_classification Prognosis Virology Infectious Diseases Cross-Sectional Studies Phenotype HIV p24 Antigen Immunology Female Viral disease beta 2-Microglobulin |
| Zdroj: | The Journal of infectious diseases. 168(6) |
| ISSN: | 0022-1899 |
| Popis: | The association between isolation of the syncytium-inducing (SI) phenotype of human immunodeficiency virus (HIV) and unfavorable clinical and immune status was evaluated in a cross-sectional study. Data on HIV phenotype were available for 341 of 878 persons entering clinical trials of antiretroviral therapies. Patients with SI virus were demographically similar to those with non-SI (NSI) virus but were more likely to have a diagnosis of AIDS and detectable circulating HIV p24 antigen. Patients with SI virus also had a lower CD4+ cell count and a higher serum level of beta 2-microglobulin. The association between phenotype and present status was explained statistically by CD4+ cell count. Phenotype, serum level of beta 2-microglobulin, and the presence of detectable p24 antigen were all independent predictors of present CD4+ cell count. The likelihood of finding SI virus increased with unfavorable virologic and immunologic parameters and varied with the amount of prior antiretroviral therapy. |
| Databáze: | OpenAIRE |
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