Multiparametric Magnetic Resonance Elastography Improves the Detection of NASH Regression Following Bariatric Surgery
| Autor: | Jiahui Li, Alina M. Allen, Meng Yin, Richard L. Ehman, Michael L. Kendrick, Kristin C. Mara, Kevin J. Glaser, Michael L. Wells, Timothy J. Gunneson, Joseph J. Larson, Vijay H. Shah, Travis J. McKenzie, Suzanne Greiner, Taofic Mounajjed, Sudhakar K. Venkatesh, Terry M. Therneau, Todd A. Kellogg |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Nonalcoholic steatohepatitis
Complete data medicine.medical_specialty Hepatology medicine.diagnostic_test business.industry Magnetic resonance imaging Original Articles Logistic regression Regression 030218 nuclear medicine & medical imaging Surgery Magnetic resonance elastography 03 medical and health sciences 0302 clinical medicine Biopsy medicine 030211 gastroenterology & hepatology Original Article lcsh:Diseases of the digestive system. Gastroenterology lcsh:RC799-869 business Noninvasive biomarkers |
| Zdroj: | Hepatology Communications, Vol 4, Iss 2, Pp 185-192 (2020) Hepatology Communications |
| Popis: | Disease monitoring in nonalcoholic steatohepatitis (NASH) is limited by absence of noninvasive biomarkers of disease regression or progression. We aimed to examine the role of multiparametric three‐dimensional magnetic resonance elastography (3D‐MRE) and magnetic resonance imaging proton density fat fraction (MRI‐PDFF) in the detection of NASH regression after interventions. This is a single‐center prospective clinical trial of 40 patients who underwent bariatric surgery. Imaging and liver biopsies were obtained at baseline and 1 year after surgery. The imaging protocol consisted of multifrequency 3D‐MRE to determine the shear stiffness at 60 Hz and damping ratio at 40 Hz, and MRI‐PDFF to measure the fat fraction. A logistic regression model including these three parameters was previously found to correlate with NASH. We assessed the model performance in the detection of NASH resolution after surgery by comparing the image‐predicted change in NAFLD activity score (delta NAS) to the histologic changes. A total of 38 patients (median age 43, 87% female, 30 of 38 with NAS ≥ 1, and 13 of 38 with NASH) had complete data at 1 year. The NAS decreased in all subjects with NAS ≥ 1 at index biopsy, and NASH resolved in all 13. There was a strong correlation between the predicted delta NAS by imaging and the delta NAS by histology (r = 0.73, P In this prospective clinical trial, multiparametric 3D‐MRE and MRI‐PDFF detected histologic changes of NASH resolution after bariatric surgery. Multiparametric 3D‐MRE and MRI‐PDFF are an accurate dynamic biomarker, which can be used for noninvasive diagnosis and longitudinal monitoring of NASH. |
| Databáze: | OpenAIRE |
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