Three chromosome-scale Papaver genomes reveal punctuated patchwork evolution of the morphinan and noscapine biosynthesis pathway
| Autor: | Yizhuo Che, Xiaofei Yang, Bo Wang, Jianyong Sun, Tun Xu, Jiadong Lin, Peng Jia, Jian Zhou, Yanyan Jia, Li Guo, Shenghan Gao, Kai Ye |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Noscapine
Science General Physics and Astronomy Genomics Biology Genome Benzylisoquinolines General Biochemistry Genetics and Molecular Biology Article Evolutionary genetics Chromosomes Evolution Molecular chemistry.chemical_compound Alkaloids Gene cluster Papaver Benzylisoquinoline Gene Plant Proteins Multidisciplinary Comparative genomics Chromosome General Chemistry biology.organism_classification Genome evolution Biosynthetic Pathways Metabolic pathway chemistry Morphinans Evolutionary biology Genome duplication Multigene Family |
| Zdroj: | Nature Communications Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021) Nature Communications, 12(1). NATURE PORTFOLIO |
| ISSN: | 2041-1723 |
| Popis: | For millions of years, plants evolve plenty of structurally diverse secondary metabolites (SM) to support their sessile lifestyles through continuous biochemical pathway innovation. While new genes commonly drive the evolution of plant SM pathway, how a full biosynthetic pathway evolves remains poorly understood. The evolution of pathway involves recruiting new genes along the reaction cascade forwardly, backwardly, or in a patchwork manner. With three chromosome-scale Papaver genome assemblies, we here reveal whole-genome duplications (WGDs) apparently accelerate chromosomal rearrangements with a nonrandom distribution towards SM optimization. A burst of structural variants involving fusions, translocations and duplications within 7.7 million years have assembled nine genes into the benzylisoquinoline alkaloids gene cluster, following a punctuated patchwork model. Biosynthetic gene copies and their total expression matter to morphinan production. Our results demonstrate how new genes have been recruited from a WGD-induced repertoire of unregulated enzymes with promiscuous reactivities to innovate efficient metabolic pathways with spatiotemporal constraint. Papaver species P. setigerum, P. rhoeas, and P. somniferum accumulates different levels of morphine and noscapine. Here, the authors report the improved genome assembly of P. somniferum and de novo assembly of the other two species, and reveal the evolution of the benzylisoquinoline alkaloids biosynthetic pathway. |
| Databáze: | OpenAIRE |
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