Investigation on ERCC5 genetic polymorphisms and the development of gastric cancer in a Chinese population

Autor: Sun Hf, Long Yang, Yingchi Zhang
Rok vydání: 2016
Předmět:
Adult
Male
Risk
0301 basic medicine
Oncology
medicine.medical_specialty
Gene Expression
Single-nucleotide polymorphism
Logistic regression
Polymerase Chain Reaction
Polymorphism
Single Nucleotide
03 medical and health sciences
0302 clinical medicine
Asian People
Gene Frequency
Stomach Neoplasms
Internal medicine
Genotype
Odds Ratio
Genetics
medicine
Humans
Genetic Predisposition to Disease
Allele
Promoter Regions
Genetic
Molecular Biology
Genotyping
Alleles
Aged
Chinese population
business.industry
Significant difference
Nuclear Proteins
General Medicine
Middle Aged
Endonucleases
DNA-Binding Proteins
Logistic Models
030104 developmental biology
Case-Control Studies
030220 oncology & carcinogenesis
Female
Gene polymorphism
business
Polymorphism
Restriction Fragment Length
Transcription Factors
Zdroj: Genetics and Molecular Research. 15
ISSN: 1676-5680
Popis: Our study aimed to investigate the role of 2 ERCC5 promoter SNPs (rs2094258 and rs751402) in the development of gastric cancer in the Chinese population. The present hospital-based case-control study consisted of 155 patients with gastric cancer and 246 healthy controls recruited between March 2012 and December 2014. Genotyping for the rs2094258 and rs751402 polymorphic sites was carried out using polymerase chain reaction-restriction fragment length polymorphism. Statistical analyses were conducted using the SPASS version 16.0 software (SPSS, Inc., Chicago, IL, USA). As determined by the chi-square test, there was a significant difference in the genotype distributions of rs751402 between patients and controls (X2 = 6.74, P = 0.03). By unconditional logistic regression analysis, we observed that the TT genotype in rs751402 was significantly associated with increased risk to gastric cancer as compared with the CC genotype, and the adjusted OR (95%CI) was 2.17 (1.15-4.09). Moreover, subjects carrying the T allele in rs751402 had elevated risk of developing gastric cancer when compared with those carrying the C allele, with an adjusted OR value (95%CI) of 1.47 (1.09-1.99). In conclusion, we suggest that the ERCC5 rs751402 gene polymorphism may influence the susceptibility to gastric cancer in the Chinese population.
Databáze: OpenAIRE
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