Chemical Constituents and Pharmacology properties of Aristolochia triangularis: a south brazilian highly-consumed botanical with multiple bioactivities
| Autor: | Sérgio Augusto de Loreto Bordignon, Argyro Vontzalidou, Flávio Henrique Reginatto, Tatiana da Rosa Guimarães, Cesar Paulo Simionato, Jadel M. Kratz, Cláudia Maria Oliveira Simões, Mário Steindel, Danielle T.M. Costa, Eloir Paulo Schenkel, Vitor Clasen Chaves, Simone Quintana de Oliveira, Sapfo Dimitrakoudi |
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| Rok vydání: | 2019 |
| Předmět: |
Antifungal Agents
medicine.drug_class medicine.medical_treatment Phytochemicals Antiprotozoal Agents Fractionation Chemical Fractionation Antiviral Agents 01 natural sciences Aristolochia chemistry.chemical_compound antiproliferative medicine Humans lcsh:Science Antidote Chromatography High Pressure Liquid Lignan Multidisciplinary Ethanol Chloroform biology Traditional medicine Plant Extracts 010405 organic chemistry Aristolochia triangularis Antimicrobial biology.organism_classification Anti-Bacterial Agents 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry antiprotozoal Antiprotozoal antimicrobial lcsh:Q aristolochic acids Brazil antiherpes |
| Zdroj: | Anais da Academia Brasileira de Ciências v.91 n.3 2019 Anais da Academia Brasileira de Ciências Academia Brasileira de Ciências (ABC) instacron:ABC Anais da Academia Brasileira de Ciências, Vol 91, Iss 3 |
| ISSN: | 1678-2690 0001-3765 |
| Popis: | Aristolochia triangularis Cham., is one of the most frequently used medicinal plant in Southern Brazil. Preparations containing the leaves and/or stems are traditionally used as anti-inflammatory, diuretic, as well as antidote against snakebites. This study screened A. triangularis extracts, fractions and isolated compounds for different bioactivities. A weak antiproliferative activity against human lung cancer cell line (A549) was observed only for chloroform fraction obtained from stems (CFstems - CC50: 2.93 µg/mL). Also, a moderate antimicrobial activity against Staphylococcus aureus was detected just for chloroform fraction obtained from leaves (CFleaves -13-16 mm inhibition zone). Additionally, two semi-purified fractions (CFstems-4 and CFleaves-4) selectively inhibited HSV-1 replication (IC50 values of 0.40 and 2.61 µg/mL, respectively), while only CFleaves showed promising results against Leishmania amazonensis. Fractionation of extracts resulted in the isolation of one neolignan (-) cubebin and one lignan (+) galbacin. However, these compounds are not responsible for the in vitro bioactivities herein detected. The presence of aristolochic acid I and aristolochic acid II in the crude ethanol extract of stems (CEEstems) and leaves (CEEleaves) was also investigated. The HPLC analysis of these extracts did not display any peak with retention time or UV spectra comparable to aristolochic acids I and II. |
| Databáze: | OpenAIRE |
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