Prognostic implications of pulmonary wave reflection and reservoir pressure in patients with pulmonary hypertension
| Autor: | Colm McCabe, Alexander Kempny, Wei Li, Andrew Constantine, K. Wustmann, Justin E. Davies, Dudley J. Pennell, Darrel P. Francis, Konstantinos Dimopoulos, Laura C. Price, Raad H. Mohiaddin, Stephen J. Wort, Michael A. Gatzoulis |
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| Rok vydání: | 2021 |
| Předmět: |
Reservoir pressure
medicine.medical_specialty medicine.diagnostic_test business.industry Pulmonary ventriculo-arterial coupling Pulsatile flow Hemodynamics Magnetic resonance imaging medicine.disease Wave intensity analysis Right ventricular function Pulmonary hypertension Compliance (physiology) Blood pressure Afterload RC666-701 Internal medicine medicine Cardiology Diseases of the circulatory (Cardiovascular) system In patient business |
| Zdroj: | International Journal of Cardiology Congenital Heart Disease, Vol 5, Iss, Pp 100199-(2021) |
| Popis: | Background: Right ventricular (RV) coupling to the pulmonary circulation influences the response of the RV to the increased afterload caused by pulmonary hypertension (PH), which ultimately determines prognosis. A methodology that accounts for pulsatile flow is required when assessing ventriculo-arterial coupling. We applied wave intensity analysis (WIA) methods to assess the compliance of the main pulmonary artery (PA) in patients with or without PH and compared this to PA distensibility, RV function and clinical outcomes. Methods: High-fidelity blood pressure and Doppler flow velocity tracings were obtained simultaneously during cardiac catheterisation for suspected PH. RV volumes, main PA distensibility and ventriculo-arterial coupling (Emax/Ea) were analysed using cardiovascular magnetic resonance. Results: The study included 17 PH patients and 6 controls. Wave speed, reservoir and excess pressure were higher in PH patients compared to controls (p |
| Databáze: | OpenAIRE |
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