In Compressed Lung Tissue Microscopic Sections of Adenocarcinoma In Situ May Mimic Papillary Adenocarcinoma
| Autor: | Rutger J. Lely, Lorine B. Meijer-Jorna, Erik Thunnissen, Koen J. Hartemink, Yasushi Yatabe, Jeroen A. M. Beliën, Masayuki Noguchi, David M. Hwang, Ming-Sound Tsao, Jin-Haeng Chung, Douglas B. Flieder, Keith Kerr |
|---|---|
| Přispěvatelé: | Pathology, Radiology and nuclear medicine, Cardio-thoracic surgery, CCA - Oncogenesis |
| Rok vydání: | 2013 |
| Předmět: |
Male
Pathology medicine.medical_specialty Lung Neoplasms Atelectasis Adenocarcinoma Specimen Handling Pathology and Forensic Medicine Diagnosis Differential fluids and secretions Papillary adenocarcinoma X ray computed Biomarkers Tumor medicine Humans Elastin metabolism Lung Aged 80 and over Histocytochemistry Chemistry Adenocarcinoma in situ General Medicine Anatomy Middle Aged biochemical phenomena metabolism and nutrition medicine.disease Elastin Adenocarcinoma Papillary Medical Laboratory Technology Female Artifacts Tomography X-Ray Computed Lung tissue |
| Zdroj: | Thunnissen, E, Belien, J A M, Kerr, K M, Chung, J H, Flieder, D B, Noguchi, M, Yatabe, Y, Hwang, D M, Lelij, R J, Hartemink, K J, Meijer-Jorna, L B & Tsao, M S 2013, ' In compressed lung tissue microscopic sections of adenocarcinoma in situ may mimic papillary adenocarcinoma ', Archives of pathology & laboratory medicine, vol. 137, no. 12, pp. 1792-1797 . https://doi.org/10.5858/arpa.2012-0613-SA Archives of pathology & laboratory medicine, 137(12), 1792-1797. College of American Pathologists |
| ISSN: | 1543-2165 0003-9985 |
| Popis: | Surgical removal and pathologic handling of lung tissue has a compressive effect upon its architecture. The effect of surgical atelectasis on morphology has not been examined in depth, especially with respect to lung adenocarcinomas.To examine the influence of surgical atelectasis on morphologic lepidic growth pattern, mimicking papillary adenocarcinoma pattern.In 2 cases serial sections of resected pulmonary adenocarcinoma were used, as was a 3-dimensional reconstruction. Elastin stains were performed on primary and metastatic adenocarcinomas.Perfusion fixation of another case showed marked morphologic differences of less compressed peripheral lung tissue, emphasizing the preexisting alveolar structure. An elastic stain may help identify true lesional architecture.We demonstrate that microscopic sections of adenocarcinoma in situ in compressed/collapsed tissue may give rise to a pseudopapillary pattern mimicking invasive adenocarcinoma. Accurate appreciation of different tumor architecture in lung adenocarcinoma has important biologic and clinical implications. Pathologists should be aware of the possibility of misclassification of adenocarcinoma pattern due to tissue artifacts caused by lung tissue handling. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|