Stromal striae: a new insight into corneal physiology and mechanics
| Autor: | Thu-Mai Nguyen, Kate Grieve, Amir Nahas, Karsten Plamann, Romain Bocheux, Marie-Claire Schanne-Klein, Djida Ghoubay, Cristina Georgeon, Marie Borderie, Felipe Andreiuolo, Vincent Borderie, Caroline Crotti, Gaël Latour |
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| Přispěvatelé: | Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts (CHNO), Institut de la Vision, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Imagerie et Modélisation en Neurobiologie et Cancérologie (IMNC (UMR_8165)), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut Langevin - Ondes et Images (UMR7587) (IL), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'optique appliquée (LOA), École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Optique et Biosciences (LOB), École polytechnique (X)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), HAL UPMC, Gestionnaire, Sorbonne Université (SU)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Paris (UP)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Intraocular pressure Pathology genetic structures Lumican lcsh:Medicine Corneal Diseases Mice 0302 clinical medicine Collagen VI Prospective Studies lcsh:Science Aged 80 and over Multidisciplinary Anatomy Middle Aged Biomechanical Phenomena [SDV.MHEP.OS] Life Sciences [q-bio]/Human health and pathology/Sensory Organs Elasticity Imaging Techniques Collagen Tomography Optical Coherence Adult Keratoconus medicine.medical_specialty [SDV.MHEP.AHA] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] Stromal cell Adolescent Corneal Stroma Biology Article 03 medical and health sciences Stroma medicine [SDV.MHEP.AHA]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] Animals Humans [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs Descemet Membrane Intraocular Pressure Aged Shear wave elastography lcsh:R medicine.disease eye diseases 030104 developmental biology Microscopy Electron Scanning 030221 ophthalmology & optometry Macaca lcsh:Q sense organs Keratocan |
| Zdroj: | Scientific Reports Scientific Reports, 2017, 7, pp.13584. ⟨10.1038/s41598-017-13194-6⟩ Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017) Scientific Reports, Nature Publishing Group, 2017, 7, pp.13584. ⟨10.1038/s41598-017-13194-6⟩ |
| ISSN: | 2045-2322 |
| Popis: | We uncover the significance of a previously unappreciated structural feature in corneal stroma, important to its biomechanics. Vogt striae are a known clinical indicator of keratoconus, and consist of dark, vertical lines crossing the corneal depth. However we detected stromal striae in most corneas, not only keratoconus. We observed striae with multiple imaging modalities in 82% of 118 human corneas, with pathology-specific differences. Striae generally depart from anchor points at Descemet’s membrane in the posterior stroma obliquely in a V-shape, whereas in keratoconus, striae depart vertically from posterior toward anterior stroma. Optical coherence tomography shear wave elastography showed discontinuity of rigidity, and second harmonic generation and scanning electron microscopies showed undulation of lamellae at striae locations. Striae visibility decreased beyond physiological pressure and increased beyond physiological hydration. Immunohistology revealed striae to predominantly contain collagen VI, lumican and keratocan. The role of these regions of collagen VI linking sets of lamellae may be to absorb increases in intraocular pressure and external shocks. |
| Databáze: | OpenAIRE |
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