Reciprocal inhibition between sensory ASH and ASI neurons modulates nociception and avoidance in Caenorhabditis elegans
| Autor: | Zijing Xu, Wei-Pin Niu, Lan-Lan Li, Ming-Hai Ge, Tai-Hong Wu, Chang-Li Ge, Shi-Ping Wu, Yan-Xue Song, Maha T. H. Al-Mhanawi, Min Guo, Zheng-Xing Wu, Chun-Ming Su |
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| Rok vydání: | 2015 |
| Předmět: |
Nociception
Serotonin Copper Sulfate Genotype Sensory Receptor Cells General Physics and Astronomy Neuropeptide Sensory system General Biochemistry Genetics and Molecular Biology Interneurons mental disorders Avoidance Learning Animals Caenorhabditis elegans Caenorhabditis elegans Proteins Receptor Octopamine Neurons Microscopy Confocal Multidisciplinary Behavior Animal biology Neuropeptides Nociceptors Reciprocal inhibition General Chemistry Anatomy biology.organism_classification Biomechanical Phenomena Mutation Calcium Octopamine (neurotransmitter) Neuroscience Copper Signal Transduction |
| Zdroj: | Nature Communications. 6 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/ncomms6655 |
| Popis: | Sensory modulation is essential for animal sensations, behaviours and survival. Peripheral modulations of nociceptive sensations and aversive behaviours are poorly understood. Here we identify a biased cross-inhibitory neural circuit between ASH and ASI sensory neurons. This inhibition is essential to drive normal adaptive avoidance of a CuSO4 (Cu(2+)) challenge in Caenorhabditis elegans. In the circuit, ASHs respond to Cu(2+) robustly and suppress ASIs via electro-synaptically exciting octopaminergic RIC interneurons, which release octopamine (OA), and neuroendocrinally inhibit ASI by acting on the SER-3 receptor. In addition, ASIs sense Cu(2+) and permit a rapid onset of Cu(2+)-evoked responses in Cu(2+)-sensitive ADF neurons via neuropeptides possibly, to inhibit ASHs. ADFs function as interneurons to mediate ASI inhibition of ASHs by releasing serotonin (5-HT) that binds with the SER-5 receptor on ASHs. This elaborate modulation among sensory neurons via reciprocal inhibition fine-tunes the nociception and avoidance behaviour. |
| Databáze: | OpenAIRE |
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