Mild copper-catalyzed N-arylation of azaheterocycles with aryl halides
| Autor: | Paul C. J. Kamer, Gino P. F. van Strijdonck, Adri van den Hoogenband, Jan Willem Terpstra, Mark Kuil, Piet W. N. M. van Leeuven, Gerben M. Visser, E. Koen Bekedam |
|---|---|
| Přispěvatelé: | Homogeneous and Supramolecular Catalysis (HIMS, FNWI) |
| Rok vydání: | 2005 |
| Předmět: |
bond formation
Base (chemistry) chemistry.chemical_element Halide Biochemistry Medicinal chemistry efficient chemistry.chemical_compound arylboronic acids Drug Discovery Levensmiddelenchemie Organic chemistry organic-synthesis Amination VLAG chemistry.chemical_classification goldberg reactions Food Chemistry Ligand Aryl Organic Chemistry amination ullmann synthesis General Medicine Copper Organische Chemie chemistry nitrogen-heterocycles imidazoles Copper catalyzed Organic synthesis c-n |
| Zdroj: | Tetrahedron Letters, 46(14), 2405-2409 Tetrahedron Letters 46 (2005) 14 Tetrahedron Letters, 46(14), 2405-2409. Elsevier |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/j.tetlet.2005.02.074 |
| Popis: | A highly efficient copper(I)-catalyzed N -arylation of azaheterocycles with various aryl halides is reported. The N -arylation reaction can be carried out using as low as 0.5 mol % of (Cu(I)OTf) 2 ·PhH and 1.0 mol % of 4,7-dichloro-1,10-phenanthroline as the ligand. Furthermore, cheap and stable copper precursors like Cu(I)I and Cu(II)(OAc) 2 ·H 2 O and the cheap and mild base K 2 CO 3 can be used. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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