Cytotoxic derivatives of withanolides isolated from the leaves of Acnistus arborescens
| Autor: | Lauro Euclides Soares Barata, Geoffrey A. Cordell, Sandro Minguzzi |
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| Jazyk: | portugalština |
| Rok vydání: | 2011 |
| Předmět: |
biology
human lung cancer Human lung cancer Stereochemistry Acnistus arborescens General Chemistry biology.organism_classification Molecular biology In vitro lcsh:Chemistry chemistry.chemical_compound lcsh:QD1-999 Withanolide chemistry Epidermoid carcinoma withanolides derivatives Acetylation Solanaceae Human colon |
| Zdroj: | Química Nova, Volume: 34, Issue: 2, Pages: 237-241, Published: 2011 Química Nova, Vol 34, Iss 2, Pp 237-241 (2011) Química Nova v.34 n.2 2011 Química Nova Sociedade Brasileira de Química (SBQ) instacron:SBQ |
| Popis: | In view of anticancer activity of 7 β-acetoxywithanolide D (2) and 7β-16α-diacetoxywithonide D (3), isolated from the leaves of Acnistus arborescens (Solanaceae), five withanolide derivatives were obtained and their structures were determined by NMR, MS and IV data analysis. The in vitro anticancer activity of these derivatives was evaluated in a panel of cancer cell lines: human breast (BC-1), human lung (Lu1), human colon (Col2) and human oral epidermoid carcinoma (KB). Compounds 2a (acetylation of 2), 3b (oxidation of 3) and 2c (hydrogenation of 2) exhibited the highest anticancer activity against human lung cancer cells, with ED50 values of 0.19, 0.25 and 0.63 μg/mL, respectively. |
| Databáze: | OpenAIRE |
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